Results 51 to 60 of about 872,744 (314)

Landscape and tourism potential in the protected landscape areas [PDF]

open access: yesAgricultural Economics (Zemědělská ekonomika), 2011
Reasons to travel and to visit concrete destinations in the Czech Republic are especially the nature and cultural/historical sightseeing. The presented paper specializes on the first reason and it studies the specific landscape features together with the primary tourism potentials.
Jana MIKULEC, Michaela ANTOUŠKOVÁ
openaire   +2 more sources

Is TRIPS suffering from Big Giant’s Syndrome: Good Economics versus Self Interest? [PDF]

open access: yes, 2001
The paper discusses TRIPS as a protection measure on knowledge and new technologies through property rights and analyses the Southern concern if protection of new technologies by means of TRIPS may mean that South can no longer imitate the North in ...
Dawood, Mamoon
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Heritage Protection Versus Individual Interests in a Post-Socialist Country: the Case of Mšeno, Czech Republic [PDF]

open access: yes, 2015
Large-scale investment is routinely believed to be the main danger to urban heritage. The measures designed to sustain heritage thus traditionally focus on steering investment into respectful ways of real-estate development.
Nowotny, Vojta   +2 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

CONSIDERATIONS REGARDING THE PLANNING OF PROTECTED AREAS ARISING FROM A STUDY OF THE TUSCANIA NATURAL RESERVE (CENTRAL ITALY)

open access: yesJournal of Agricultural Engineering, 2012
Following the increase in protected territories over recent years, emphasis has been laid on improving nature conservation and management effectiveness. In particular, special attention has been given to areas where the interaction between people and the
Antonio Leone   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

LANDSCAPE PROTECTION IN GAS PRODUCTION

open access: yes, 2022
Due to the growing gas production in the country and the growing demand for oil products, one of the challenges we face is the comprehensive and rational use of our mineral resources and their preservation and protection.
Togayev A.I   +2 more
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Promoting Urban Ecosystems by Integrating Urban Ecosystem Disservices in Inclusive Spatial Planning Solutions

open access: yesLand
Ecosystem disservices (EDS)—ecosystem properties and functions that cause discomfort or harm—often shape public attitudes to urban biodiversity more strongly than ecosystem services, yet they remain weakly integrated into inclusive spatial planning. This
Anton Shkaruba   +3 more
doaj   +1 more source

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