Results 111 to 120 of about 432,625 (307)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Temperature, phenology, and turf macroalgae drive seascape change: Connections to mid‐trophic level species

Ecosphere, 2019
Landscape patterns created by the structure and form of foundational species shape ecological processes of community assembly and trophic interactions. In recent years, major shifts in foundation species have occurred in multiple ecosystems. In temperate
Jennifer A. Dijkstra, Amber Litterer, Kristen Mello, Brandon S. O'Brien, Yuri Rzhanov   +4 more
doaj   +1 more source

[Imaginary Landscapes Student Demos 41]

, 2003
Wet on wet landscape in black and light blue. On same sheet as [Imaginary Landscapes Student Demos 40]Tiff file: 3320x2630 pixels, 26 Mb; Display: jpeg, 600x757 pixels ...
Father Edward Catich
core  

The landscape as a geosystem

Geoforum, 1976
Abstract The main object of study of geography is the landscape sphere that includes the surface of our planet. The landscape sphere differs from the other geospheres by displaying unusual complexity and consists of structured sets of components which exhibit discernible relationships with one another and operate as a system.
openaire   +1 more source

Musealized landscapes and petrified landscapes

Polish Journal of Landscape Studies, 2020
The text aims to reflect upon the notion of landscape in the context of exhibitions; more precisely, it aims to do so in relation to the musealization of archaeological heritage and presentation of archaeology. The last 30 years of museum transformations, referred to as “the age of museums,” and the digital shift in museology have had a significant ...
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Exploring the relationship between cultural ecosystem services and human well-being of Qiandao Lake in China: insights from tourists and residents

Environmental Research Communications
Landscapes of lakes have a significant impact on people’s perceptions of Cultural Ecosystem Services (CES), as well as on their overall sense of well-being.
Jie Wang, Kuan Wang, Shuangjin Li, Huiyong Song, Shuang Ma, Weiwu Han, Di Pang   +6 more
doaj   +1 more source

[Imaginary Landscapes Student Demos 39]

, 2003
Wet on wet landscape in blue-grey and red-brown. On same sheet as [Imaginary Landscapes Student Demos 38]Tiff file: 3330x2420 pixels, 23.1 Mb; Display: jpeg, 581x800 pixels ...
Father Edward Catich
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

[Imaginary Landscapes Student Demos 38]

, 2003
Wet on wet landscape in blue-grey and red. On same sheet as [Imaginary Landscapes Student Demos 39]Tiff file: 3310x2010 pixels, 19 Mb; Display: jpeg, 486x800 pixels ...
Father Edward Catich
core