Results 41 to 50 of about 123,449 (249)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Towards Resilient Regions: Policy Recommendations for Stimulating Synergy between Tourism and Landscape

open access: yesLand, 2020
To make regions more resilient, a useful idea is that of synergy between tourism and landscape (i.e., a win-win situation). To help policymakers manage for synergy, we provide practical recommendations.
Jasper Heslinga   +2 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mainstreaming agrobiodiversity in planet-friendly school meals for children: a scoping review

open access: yesThe Lancet Planetary Health
Summary: The global shift away from healthy, diverse, and sustainable diets threatens children’s health and futures. Although school gardens and home-grown school feeding can reconnect children with nutritious, sustainably produced food, these ...
Natalia Estrada-Carmona, PhD   +13 more
doaj   +1 more source

Migration, Continuity and Creativity in the Tropics

open access: yeseTropic: electronic journal of studies in the tropics, 2013
Tropical Australia is a multicultural mosaic fashioned by various waves of migration and ancient Indigenous cultures. Migration, cultural diversity and multiculturalism have been at the heart of nation building in Australia. Tropical Australia represents
Hurriyet Babacan, Alperhan Babacan
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Identifying critical incentives for scaling out the adoption of agroecological practices–a systematic review of Peruvian cacao value chains

open access: yesInternational Journal of Agricultural Sustainability
The growing global importance of agroecology highlights the pivotal role public and private sectors play in providing incentives and investments to catalyze behavioural changes and transform food systems.
Jonathan Mockshell   +5 more
doaj   +1 more source

EVOLUTION OF THE IMPERIAL RESIDENCE AND URBAN DEVELOPMENT OF THE ST. PETERSBURG CENTER

open access: yesArchitecture and Engineering, 2019
The scale and nature of the impact of the imperial residence in St. Petersburg on the urban environment of the city center are considered. It is noted that St.
Leonid Lavrov, Fedor Perov
doaj   +1 more source

Lane's landscapes [PDF]

open access: yesNature, 1998
Biologists such as Nancy Lane are venturing into previously unexplored and strangely beautiful realms of the cell, using sophisticated microscopes allied with familiar, age-old visual techniques.
openaire   +2 more sources

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