Results 51 to 60 of about 132,944 (268)
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Robotic 3DCP fabrication of custom-fit slabs for irregular pontoons
Architectural IntelligenceThis paper presents a case study on the use of 3D concrete printing (3DCP) to qualify rocky pontoons with spaces for recreational use—namely sitting areas, circulation trails and fishing spots—and biodiversity protection—providing habitat and refuge for ...
João Ribeiro +5 more
doaj +1 more source
HeritageOur study reveals multiple signals of Palaeolithic occupation in the Flemish Valley, a large depression in coastal northwestern Europe with an extremely sparse Pleistocene archaeological record until now.
Philip Van Peer +3 more
doaj +1 more source
EVOLUTION OF THE IMPERIAL RESIDENCE AND URBAN DEVELOPMENT OF THE ST. PETERSBURG CENTER
Architecture and Engineering, 2019 The scale and nature of the impact of the imperial residence in St. Petersburg on the urban environment of the city center are considered. It is noted that St.
Leonid Lavrov, Fedor Perov
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Methis: Studia Humaniora Estonica, 2014 The article examines two novels published during the early years of Karl Ristikivi’s exile, All That Ever Was (1946) and Nothing Happened (1947), and his poetry from 1950s.
Õnne Kepp
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source