Results 41 to 50 of about 432,625 (307)
Landscapes without landscape architects. The ecological beauty of informal urban landscapes
Regarding the maintenance of urban green infrastructure, most stakeholders prefer achieving an oversimplified aesthetic archetype of cleanliness and order at the cost of high maintenance, whilst landscape architects try to reproduce islands of near-natural vegetation even where the environmental factors typical of urban areas do not allow it.
Catalano C. +3 more
openaire +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Tweets in the Peak: Twitter Analysis - the impact of Covid-19 on cultural landscapes
The Covid-19 pandemic had an unprecedented impact on society, with restrictions on socialising and movement during the three lockdown periods between March 2020 and March 2021 (Baker et al. 2021; Institute for Government Analysis 2021). Easily accessible
Martina Tenzer
doaj +1 more source
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Wet on wet landscape with building shapes; black, green and yellow foreground; black and red sky. On same sheet as [Stage Two Landscapes 24]Tiff file: 2120x3330 pixels, 20.2 Mb; Display: jpeg, 530x797 pixels ...
Father Edward Catich
core +1 more source
United Nations Educational Scientific and Cultural Organization (UNESCO) Biosphere Reserves strive for a harmonious interaction between humans and nature.
Bettina Hedden-Dunkhorst +1 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Wet on wet landscape of white, gray, green; blue houses; black foreground and blue sky. On same sheet as [Stage Two Landscapes 21].Tiff file: 2220x3330 pixels, 21.2 Mb; Display: jpeg, 533x800 pixels ...
Father Edward Catich
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

