Results 41 to 50 of about 132,944 (268)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Land, 2020 United Nations Educational Scientific and Cultural Organization (UNESCO) Biosphere Reserves strive for a harmonious interaction between humans and nature.
Bettina Hedden-Dunkhorst +1 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Mainstreaming agrobiodiversity in planet-friendly school meals for children: a scoping review
The Lancet Planetary HealthSummary: The global shift away from healthy, diverse, and sustainable diets threatens children’s health and futures. Although school gardens and home-grown school feeding can reconnect children with nutritious, sustainably produced food, these ...
Natalia Estrada-Carmona, PhD +13 more
doaj +1 more source
Land, 2020 To make regions more resilient, a useful idea is that of synergy between tourism and landscape (i.e., a win-win situation). To help policymakers manage for synergy, we provide practical recommendations.
Jasper Heslinga +2 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
International Journal of Agricultural SustainabilityThe growing global importance of agroecology highlights the pivotal role public and private sectors play in providing incentives and investments to catalyze behavioural changes and transform food systems.
Jonathan Mockshell +5 more
doaj +1 more source
Migration, Continuity and Creativity in the Tropics
eTropic: electronic journal of studies in the tropics, 2013 Tropical Australia is a multicultural mosaic fashioned by various waves of migration and ancient Indigenous cultures. Migration, cultural diversity and multiculturalism have been at the heart of nation building in Australia. Tropical Australia represents
Hurriyet Babacan, Alperhan Babacan
doaj +1 more source