Results 71 to 80 of about 132,944 (268)
Ecology and EvolutionHabitat degradation and associated reductions in ecosystem functions can be reversed by reintroducing or ‘rewilding’ keystone species. Rewilding projects have historically targeted restoration of processes such as grazing regimes or top‐down predation ...
Peter Contos +6 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
HeritageDevelopment of the continental shelf has accelerated significantly as nations around the world seek to harness offshore renewable energy. Many areas marked for development align with submerged palaeolandscapes. Poorly understood and difficult to protect,
Vincent Gaffney +5 more
doaj +1 more source
Internet Archaeology, 2004 The discipline of archaeology studies the nature, meanings and effects of past human behaviour over time and space. Moreover, it seeks to clarify the processes that determined this behaviour (Barrett 2001, 144) through the study of material culture and ...
Doortje van Hove, Ulla Rajala
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Musealized landscapes and petrified landscapes
Polish Journal of Landscape Studies, 2020 The text aims to reflect upon the notion of landscape in the context of exhibitions; more precisely, it aims to do so in relation to the musealization of archaeological heritage and presentation of archaeology. The last 30 years of museum transformations, referred to as “the age of museums,” and the digital shift in museology have had a significant ...
openaire +2 more sources
PLoS Biology, 2003 Open-access publication is inarguably valuable to science and to the public, yet skepticism about the long-term sustainability of open-access publications persists (see Nature, October 9, and Science, October 24). While some fear the effects of the open-access model—which shifts revenue streams from subscription fees to publication fees—on scientific ...
Helen Doyle, Andy Gass, Debra Lappin
openaire +4 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A framework for monitoring ecosystem restoration at landscape scale
Conservation Science and PracticeSuccessful large‐scale ecosystem restoration projects are central to achieving ambitious global and regional restoration targets, but evidence on outcomes is scarce.
Nancy Ockendon +5 more
doaj +1 more source
Analyzing Cultural Markers to Characterize Regional Identity for Rural Planning
Rural Landscapes: Society Environment History, 2018 Regional identity is the shared sense of regional one-ness, distinctiveness and difference. However, it is an undervalued factor to promote development in lagging rural areas and little is known about methods to reveal its content.
Falco Knaps, Sylvia Herrmann
doaj +1 more source