Results 41 to 50 of about 211,324 (292)
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Using scenarios to explore UK upland futures [PDF]
, 2009 Uplands around the world are facing significant social, economic and environmental changes, and decision-makers need to better understand what the future may hold if they are to adapt and maintain upland goods and services.
Arblaster, K. +14 more
core +2 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Issues and Strategies for the Conservation of the Artificial Water System in Hongcun, China [PDF]
SHS Web of Conferences, 2019 Since 2012, the Chinese Government has proposed the preservation concept of the “Traditional Village” in order to conserve the heritage of historic centres at the village-scale throughout China, which are being profoundly influenced by modernization ...
Li Tingshen
doaj +1 more source
What Green Economy? Diverse agendas, their tensions and potential futures [PDF]
, 2014 The 'green economy' has become a prominent global concept for debating desirable futures, while recasting or marginalising ‘sustainable development’.
Levidow, Les
core
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
4D‐Printed Magneto‐Plasmonic Microrobots for Programmable Spatiotemporal De‐Icing
Advanced Functional Materials, EarlyView.A 4D‐printing strategy is introduced to achieve programmable de‐icing devices. By aligning gold–magnetite nanofillers within a photosensitive resin, the printed structures exhibit dual magnetic and plasmonic functionalities, enabling precise spatio‐temporal ice removal through thermoplasmonic effects.
Amélie Pérot +7 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim +5 more
wiley +1 more source
WOODLAND POND SALAMANDER ABUNDANCE IN RELATION TO FOREST MANAGEMENT AND ENVIRONMENTAL CONDITIONS IN NORTHERN WISCONSIN [PDF]
, 2015 Woodland ponds are important landscape features that help sustain populations of amphibians that require this aquatic habitat for successful reproduction.
Beck, Albert J. +5 more
core +2 more sources