Results 141 to 150 of about 2,449,627 (313)

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Rapid and Efficient Affinity Isolation of Engineered Extracellular Vesicles Encapsulating Functional Proteins via Internal Twin‐Strep Tetraspanin Tagging

Small, EarlyView.
Structure‐guided internal twin‐Strep tagging of the tetraspanins CD63 or CD9 enables rapid and efficient antibody‐free affinity isolation of engineered extracellular vesicles (EVs) using Strep technology while allowing luminal protein loading. The approach removes over 96% of contaminants, separates tagged EVs from coexisting viral particles, and ...
Minh‐Tu Pham, Jona Benjamin Krohn, Janis Meyer, Christian Ritter, Martin Schneider, Dominic Helm, Dario Frey, Kleopatra Rapti, Uta Haselmann‐Weiss, Elif Toprak, Viet Loan Dao Thi, Florian Leuschner, Dirk Grimm, Karl Rohr, Ralf Bartenschlager   +14 more
wiley   +1 more source

Looking for Trouble: Pre‐Intervention Monitoring in Human and AI Driver Training

Symbolic Interaction, EarlyView.
We compare two types of situations involving monitoring of car driving: a driving instructor overseeing a trainee driver and a safety driver overseeing the performance of autonomous vehicle (AV) software. Our focus is on instances of monitoring that precede (1) interventions that are aborted before impacting the driving and (2) actual interventions on ...
Mathias Broth, Erik Vinkhuyzen, Jakob Cromdal   +2 more
wiley   +1 more source

Rule-adaptive lane-changing trajectory planning method for autonomous vehicles driven by dynamic risk information. [PDF]

Sci Rep
Zhao J, Yan X, Zhou Z, Zhang Z.
europepmc   +1 more source

Mortal relationality: waria family care and the ethics of dying in Bali Relationnalité mortelle : soins familiaux des waria et éthique des mourants à Bali

Journal of the Royal Anthropological Institute, EarlyView.
Can a good death occur for those who balance on the edges of grievability? In Bali, where death marks a transition within the cycles of reincarnation, a good death depends on the mortuary care performed by intimate others – care that may be foreclosed to those whose lives are shaped by stigma.
Sylvia Tidey
wiley   +1 more source

The Big Picture: Religion and Global Comparative History

Journal of Religious History, EarlyView.
This article considers what a ‘big picture’ approach to global religious history might look like, and in particular the implications of deploying the comparative method across much larger stretches of time and space than historians normally attend to. It will begin by reflecting on the epistemological moods that have hindered this project to date, the ...
Alan Strathern
wiley   +1 more source

Risk appetite-enhanced game-theoretic approach for modelling mandatory lane-changing behaviour in freeway merging areas. [PDF]

PLoS One
Wang B, Wang S, He G.
europepmc   +1 more source

Trajectory Planning for Lane Change with Intelligent Vehicles Using Fuzzy Logic and a Dynamic Programming and Quadratic Programming Algorithm

With the increasing demand for autonomous driving, ensuring safe and efficient lane-changing behavior in multi-lane traffic scenarios has become a key challenge.
Juncheng Wang, Jiahao Li, Shengqin Li
core   +1 more source

School Board Elections in England and Wales, 1870–1902: An Electoral Experiment?

History, EarlyView.
Abstract The 1870 Elementary Education Act enabled the creation of school boards in England and Wales. Members were directly elected by the cumulative vote. This method gave each individual voter as many votes as there were seats on a school board, in some cases up to fifteen.
ED GREEN
wiley   +1 more source

URBAN CLIMATE GOVERNANCE AND THE UNEVENNESS OF CITY NETWORKS: The Trajectory and Perspectives of the Global Covenant of Mayors for Climate and Energy in Chile

International Journal of Urban and Regional Research, EarlyView.
Abstract Scholars have widely discussed integrating local administrations into climate governance networks, focusing on networks such as the Global Covenant of Mayors or C40, whose members are mostly in the European Union or countries of the global North and premium cities managed by engaged administrations. Relatively little is known about urban‐scale
Alejandra Irigoyen Rios, Rosa Lehmann
wiley   +1 more source