Results 141 to 150 of about 5,474,804 (287)

Targeting the NR1D1–IGF2BP2–V‐ATPase Axis With Hybrid Nanovesicles Restores Macrophage Rhythms to Reverse Sepsis‐Induced Immunosuppression

open access: yesAdvanced Science, EarlyView.
Sepsis disrupts immune‐cell rhythms and weakens bacterial clearance. Biomimetic nanovesicles combining erythrocyte and inflammation‐activated macrophage membranes deliver siNR1D1 to dysfunctional macrophages, restoring the NR1D1–IGF2BP2–V‐ATPase pathway, circadian regulation, phagolysosomal acidification, and antimicrobial defense.
Lang Chen   +13 more
wiley   +1 more source

Lane County Notice of Adopted Amendment (2009-06-24)

open access: yes, 2009
37 pp. Adopted 2009-06-24. Department of Land Conservation and Development Notice of Adopted AmendmentThe ten small cities of Lane County have applied for a PAPA to the Lane County Rural Comprehensive Plan (RCP) to adopt a coordinated 20 year population ...
Lane County (Or.)
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KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

open access: yesAdvanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian   +13 more
wiley   +1 more source

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

open access: yesAdvanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English   +9 more
wiley   +1 more source

The effect of lane changing behavior on the approach ramp of a road overpass

open access: yes, 2016
Approaching the Buendia flyover along Roxas Boulevard, abrupt lane changing occurs exhibited through public vehicles who alight passengers right before the overpass, vehicles from the service lane and others who prefer to travel on less congested lanes ...
Belda, Alwyn Julian B.   +3 more
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A Dual‐Mode In Situ EV‐miRNA Profiling Platform for Machine‐Learning‐Assisted Gastric Cancer Liquid Biopsy

open access: yesAdvanced Science, EarlyView.
An in situ dual‐mode platform integrates fusogenic liposomes with localized autocatalytic DNA circuits for plasma‐derived extracellular vesicle microRNA analysis. Following membrane fusion, target miRNAs trigger feedback‐assisted LECHA amplification inside intact vesicles, generating fluorescence and electrochemical outputs. Machine learning integrates
Wenbin Li   +15 more
wiley   +1 more source

Lane changing and lane choice in a congested urban environment [PDF]

open access: yes
The goal of this thesis is to analyze lane changes and lane choice in a congested urban envi- ronment. This is possible thanks to the pNEUMA dataset, a new trac dataset resulting from a eld experiment with 10 drones ying over the central district of ...
Espadaler Clapés, Jasso
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