Results 121 to 130 of about 3,259,215 (246)

Spatiotemporally Ultrasound‐Controlled Nanoparticles Reprogramming Immunostimulatory Antigen‐Presenting Cancer‐Associated Fibroblasts to Enhance Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
We developed an ultrasound‐controlled biomimetic nanoplatform, mRNA/V@M NPs, to co‐deliver CD74 mRNA and V‐9302 for fibrotic TNBC therapy. CD74 mRNA reprograms myCAFs into antigen‐presenting apCAF cells through the CD74‐MHC II pathway, while V‐9302 induces ICD and activates MHC I‐CD8+ T cell immunity.
Chen Ai   +9 more
wiley   +1 more source

Lane County Notice of Adopted Amendment (2006-08-30)

open access: yes, 2006
73 pp. Adopted 2006-08-30. Department of Land Conservation and Development Notice of Adopted AmendmentCo-adoption of Coburg's Comprehensive Plan Text and Map Amendments by Lane County to Complete Periodic ...
Lane County (Or.)
core  

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

open access: yesAdvanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan   +11 more
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

open access: yesAdvanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon   +6 more
wiley   +1 more source

Lane County : Parks and open space plan, January 1981

open access: yes, 1981
126 pp. Bookmarks supplied by UO. Published 1980. Adopted January 1, 1981. Captured January 16, 2006.The purpose of this plan is to project and plan for the parks and open space needs of Lane County to the year 1995....
Lane County (Or.)
core   +1 more source

Design for a bedstead : sketch no. 62 [picture] /

open access: yes, 1926
Part of collection: Furniture designs for Prime Minister's Lodge and Government House, Canberra.; Inscriptions: signed "Ruth Lane-Poole, Oct 30 1926" -- in ink.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic ...
Lane Poole, Ruth, 1885-1974.
core  

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

open access: yesAdvanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng   +19 more
wiley   +1 more source

Design for upholstered chair : sketch no. 7 [picture] /

open access: yes, 1926
Part of collection: Furniture designs for Prime Minister's Lodge and Government House, Canberra.; Inscriptions: signed "Ruth Lane-Poole, 14/10/26" -- in ink.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.pic ...
Lane Poole, Ruth, 1885-1974.
core  

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

open access: yesAdvanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez   +8 more
wiley   +1 more source

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