Results 61 to 70 of about 51,953 (228)

BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

Nature Network Boston, 2021
Camille Bigenwald, Jessica Le Berichel, C. Wilk, Rikhia Chakraborty, Steven T. Chen, Alexandra Tabachnikova, Rebecca Mancusi, H. Abhyankar, M. Casanova-Acebes, I. Laface, Guray Akturk, Jenielle Jobson, Zoi Karoulia, Jerome C. Martin, J. Grout, Anahita Rafiei, Howard Lin, M. Manz, Alessia Baccarini, Poulikos I. Poulikakos, Brian D. Brown, S. Gnjatic, Amaja Lujambio, Kenneth L. McClain, J. Picarsic, Carl E. Allen, Miram Merad   +26 more
semanticscholar   +1 more source

Oral manifestation of Langerhans cell histiocytosis: a case report

BMC Oral Health, 2018
Bone necrosis of the jaw is a serious condition with a broad differential diagnosis of pathologies such as cutaneous histiocytosis, bone metastases or malignant tumours.
J. Luz, D. Zweifel, M. Hüllner, M. Bühler, M. Rücker, B. Stadlinger   +5 more
semanticscholar   +1 more source

Bagaimana Prognosis Histiocytosis? Sebuah Laporan Kasus [PDF]

, 2013
Penderita histiocytosis dengan keterlibatan multiorgan dan disertai gangguan fungsi organ mempunyai prognosis buruk dan tingkat mortalitas tinggi. Dilaporkan seorang penderita histiocytosis, usia 1 tahun 1 bulan yang datang dengan kelainan di kulit ...
Lestari, R. D. (Rini), Mulatsih, S. (Sri)   +1 more
core  

Clinical quiz. [PDF]

, 2005
J Pediatr Gastroenterol Nutr. 2005 Oct;41(4):483-4, 484. Clinical quiz. Prior AC, Selores M, Pina R, Dias JA, Costa FM, Vale L, Gomes L. Department of Pediatrics, Hospital Geral de Santo António, Portugal.
COSTA, F.M., DIAS, J.A., GOMES, L., PINA, R., PRIOR, A.C., SELORES, M., VALE, L.   +6 more
core   +1 more source

BRAF-V600E-mutated Rosai-Dorfman-Destombes disease and Langerhans cell histiocytosis with response to BRAF inhibitor.

Blood Advances, 2019
Demonstration of BRAF-V600E in Rosai-Dorfman-Destombes disease requires sensitive molecular assays and molecular-based tissue immunostain. BRAF-V600E blood testing is important for disease-monitoring BRAF-mutated histiocytosis and can guide inhibitor ...
R. Mastropolo, Allison G Close, S. Allen, K. McClain, Scott H. Maurer, J. Picarsic   +5 more
semanticscholar   +1 more source

Langerhans cell histiocytosis: Two clinical presentations in the same patient [PDF]

, 2012
Langerhans cell histiocytosis (LCH) is a heterogeneous group of diseases characterized by a pathological proliferation of cells phenotypically similar to Langerhans cells.
Lobo, I., Machado, S., Oliveira, A., Pinto-Almeida, T., Selores, M.   +4 more
core   +1 more source

Common Acute Lymphoblastic Leukemia Ph＋ Following Langerhans Cell Histiocytosis in a Multi-Malformed Child with INV (9) (p12;q13) (mat):Case Report [PDF]

, 2010
The occurrence of Langerhans cell histiocytosis (LCH) and another malignancy in the same patient is infrequent but has been recognized. The genetic changes that could be responsible for LCH and/or concomitant leukemia development are obscure. To the best
Pavelić, Jasminka, Čulić, Srdjana, Čulić, Vida   +2 more
core   +1 more source

Long-term disease control of Langerhans cell histiocytosis using combined BRAF and MEK inhibition.

Blood Advances, 2018
Treatment with a BRAF and MEK inhibitor can achieve a sustained response in BRAFV600-mutant Langerhans cell histiocytosis. Detection of plasma BRAFV600-mutant circulating tumor DNA is a promising biomarker for monitoring disease activity in this entity.
G. Awada, T. Seremet, K. Fostier, H. Everaert, B. Neyns   +4 more
semanticscholar   +1 more source

Vinblastine chemotherapy in adult patients with langerhans cell histiocytosis: a multicenter retrospective study

Orphanet Journal of Rare Diseases, 2017
BackgroundVinblastine is the standard treatment for children with Langerhans cell histiocytosis (LCH). Whether this treatment could be extended to adults with LCH is questionable.
A. Tazi, G. Lorillon, J. Haroche, A. Néel, S. Dominique, A. Aouba, J. Bouaziz, Constance de Margerie-Melon, E. Bugnet, V. Cottin, T. Comont, C. Lavigne, J. Kahn, J. Donadieu, S. Chevret   +14 more
semanticscholar   +1 more source

Dendritic Cells Cause Bone Lesions in a New Mouse Model of Histiocytosis. [PDF]

, 2015
Langerhans cell histiocytosis (LCH) is a rare disease caused by the clonal accumulation of dendritic Langerhans cells, which is often accompanied by osteolytic lesions.
Acha-Orbea, H., Busso, N., Chobaz, V., Ehirchiou, D., Grosjean, F., Lavanchy, C., Liu, A., Mordasini, V., Moullec, K., Nasi, S., Schneider, P., Vezzoni, P.   +11 more
core   +3 more sources