Results 81 to 90 of about 5,473,832 (328)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Language assessment in multilingual settings: Innovative practices across formal and informal environments

, 2022
This volume explores and addresses questions related to equitable access for assessment. It seeks to initiate a conversation among scholars about inclusive practices in language assessments.
Vallejos, Rosa, Haboud Bumachar, Marleen, Thompson, Greg, Hernández, Todd A., Rivera, Rosita L., Martinez, Glenn, Silva, Gláucia V., Rodríguez González, Eva, Dickinson, Kendra V., García, Fernando, Giráldez-Elizo, Marián, Rosales Alvarado, Haydée, Schulman, Sarah   +12 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Lexicon and Scenarios of Touch Perception: Towards Developing a Research Thesaurus

Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2019
The paper shows the important advance in sensory neuroscience achieved with a recent discovery of C-tactile system integrating mechanosensitive C fibers that innervate the hairy skin and representing the neurobiological substrate for the affective and ...
Anton A. Varlamov, Stanislav G. Inyashkin, Aleksandra V. Gorbacheva, Aleksey N. Semirechenko, Mikhail A. Osadchiy, Margarita N. Rusetskaya   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Igbo-English intrasentential codeswitching and the Matrix Language Frame model [PDF]

, 2015
This paper uses data from Igbo-English intrasentential codeswitching involving mixed nominal expressions to test the Matrix Language Frame (MLF) model.
Fagundes Camargos, Quesler; Federal University of Rondônia, Nicolle, Steve; Canada Institute of Linguistics / SIL, Muaka, Leonard; Winston Salem State University, North Carolina, Kawasha, Boniface; Savannah State University, Jerro, Kyle; University of Texas at Austin, Anderson, Gregory D.S.; Living Tongues Institute for Endangered Languages & University of South Africa (UNISA), van der Wal, Jenneke; University of Cambridge, Ngonyani, Deo; Michigan State University, Bowler, Margit; UCLA, Ahland, Michael; California State University, Long Beach, Kari, Ethelbert E.; University of Botswana / University of Port Harcourt, Michieka, Martha; East Tennessee State University, McPherson, Laura; Dartmouth College, Namyalo, Saudah; Makerere University, Korsah, Sampson; Universität Leipzig, Aly, Ann M.; University of California, Los Angeles, Glewwe, Eleanor; University of California, Los Angeles, Pacchiarotti, Sara; University of Oregon, Bosire, Mokaya; University of Oregon, Sibanda, Galen; Michigan State University, Bonfim Duarte, Fábio; Federal University of Minas Gerais, Landman, Meredith; Pomona College, Ihemere, Kelechukwu; University of Westminster, Rolle, Nicholas; University of California, Berkeley, Osam, E. Kweku; University of Ghana, Sarvasy, Hannah; Australian National University, Ihemere, K., Teo, Amos; University of Oregon, Burkholder, Ross; University of Chicago, Gluckmann, John; UCLA, Nilsson, Morgan; University of Gothenburg, Ngowa, Nancy Jumwa; Pwani University, Cahill, Michael; SIL, Safir, Ken; Rutgers, Payne, Doris L.; University of Oregon, Schwarz, Anne; Universidad Regional Amazónica IKIAM, Ahland, Colleen; SIL, Selvanathan, Naga; Rutgers, Atelela Ngunga, Armindoo Saúl; University of Eduardo Mondlane, Moodie, Jonathan; University of Melbourne   +39 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Teaching English Using Digital Flashcards to Improve Grammar Skills of Junior High School Students [PDF]

E3S Web of Conferences
Although digital flashcards are popular among English teachers, initiatives to actually measure the differences before and after using digital flashcards for teaching were relatively scarce.
Rejeki Murtiningsih Sri, Nur Khasanah Auliya, Puspitasari Evi   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source