Results 71 to 80 of about 397,461 (309)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Choice in Language: Applications in Text Analysis
, 2013 The notion of Choice provides a constant underlying theme to work in Systemic Functional Linguistics, whether this is concerned with in-depth description of the system of lexicogrammatical options available within specific languages, or with the analysis
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, 2012 As part of the internationalization of higher education, more and more European university courses are being taught in English. Exchanges between universities have grown, and students from different parts of the world now often study together.
Söderlundh, Hedda,, Söderlundh, Hedda
core +1 more source
Crossroads, 2019 Advertising texts are significant to manufacturers to promote and skyrocket products’ consumption. This study examined kinds of textual choices in advertising, accounting for their frequencies.
Taofeek O. Dalamu
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
, 2019 Choice revision is a sort of non-prioritized multiple revision, in which the agent partially accepts the new information represented by a set of sentences. We investigate the construction of choice revision based on a new approach to belief change called
Zhang, Li,
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
SECOND GENERATION LATINOS: EXPLORING\ud LANGUAGE CHOICE
, 2012 The purpose of this qualitative study was to explore the correlation of social influence and personal perception on language choice among second generation Latinos.
Hern??ndez, Maria de Jesus
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