Results 51 to 60 of about 948,935 (311)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Plurilingual competence, styles and variation

open access: yesEesti ja Soome-ugri Keeleteaduse Ajakiri, 2011
The paper explores plurilingual competence in respect to language proficiency, language education and pluri- and multilingualism. The notion of communicative competence was introduced by Hymes (1972) as a reaction to chomskyan view of language as an ...
Jyrki Kalliokoski
doaj   +1 more source

THE IMPLICATION OF FUNCTIONAL THEORY IN TEACHING READING A DESCRIPTIVE TEXT FOR MIDDLE AGE STUDENTS (Functional Communication Activities in Language Teaching) [PDF]

open access: yes, 2012
Functional theory views language as means of communication. So, communicative competence is the goal of language teaching. One of the most characteristic features of communicative language teaching is that it pays systemic attention to functional as ...
Ana, Rayda Ary
core  

Memory-Based Lexical Acquisition and Processing [PDF]

open access: yes, 1994
Current approaches to computational lexicology in language technology are knowledge-based (competence-oriented) and try to abstract away from specific formalisms, domains, and applications.
Daelemans, Walter
core   +7 more sources

The skills required for transition to university and study in biological sciences: A student perspective

open access: yesFEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

open access: yesFEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee   +6 more
wiley   +1 more source

Book Review : INTERCULTURAL LANGUAGE TEACHING AND LEARNING

open access: yesEltin Journal, 2013
The analysis of language and culture has been long and widely made.  To mention a few, Lies Sercu (2005) addresses this issue in Foreign Language Teachers and Intercultural Competence,  Soler and Jordan (ed, 2007) in Intercultural language Use and ...
Kaswan Kaswan
doaj  

Why human connection is the true metric of research success

open access: yesFEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan   +3 more
wiley   +1 more source

Дискуссия как один из методов проблемного обучения [PDF]

open access: yes, 2018
The author of the article points out the advantages of using the discussion method (which is one of the strategies of problem teaching) during foreign language classes. This strategy creates the possibility to develop various competences in learners, for
Dziewanowska, Dorota
core   +2 more sources

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