Results 121 to 130 of about 716,538 (299)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Assessing the Readability of Capital Pattern Jury Instructions [PDF]

open access: yes, 2013
Data obtained from the National Assessment of Adult Literacy (2003) indicate that 29% of adults have a Basic level of prose literacy. Prose literacy refers to the knowledge and skills needed to comprehend and use information from continuous texts, such ...
Cutler, Brian   +2 more
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Comprehension in Developmental Language Disorders

open access: yesDevelopmental Medicine & Child Neurology, 1979
SUMMARY71 language‐disordered children aged from 6 years 3 months to 13 years 1 month were compared with 281 control children aged from 3 years 9 months to 13 years 2 months on the Peabody Picture Vocabulary Test and an experimental Test for Reception of Grammar (TROG).
openaire   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

open access: yesFEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková   +3 more
wiley   +1 more source

Neural Skill Transfer from Supervised Language Tasks to Reading Comprehension

open access: yes, 2017
Reading comprehension is a challenging task in natural language processing and requires a set of skills to be solved. While current approaches focus on solving the task as a whole, in this paper, we propose to use a neural network `skill' transfer ...
Frank, Anette   +2 more
core  

Power Relations in President Bush’s State of the Union Speech [PDF]

open access: yes, 2007
Manipulation as an illegitimate exercise of power is created by means of language. Manipulative use of language enables the speaker to control other people against their best interests, the control being aimed at the recipients’ verbal contribution ...
Rudyк, І. М.
core  

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

open access: yesFEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

A process-oriented language for describing aspects of reading comprehension [PDF]

open access: yes, 1976
Includes bibliographical references (p. 36-38)The research described herein was supported in part by the National Institute of Education under Contract No.
Brown, John Seely   +2 more
core  

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