Results 181 to 190 of about 366,099 (287)

Insights into the Dynamics and Binding Mechanisms of the Alkhumra Virus NS2B/NS3 Protease: A Molecular Dynamics Study

open access: yesAdvanced Theory and Simulations, EarlyView.
The ΔRMSF$\Delta {\rm RMSF}$ analysis reveals significant flexibility differences between free NS3 and the NS2B/NS3 complex, with notable deviations in specific regions. Key residues driving NS2B binding are identified, and the protonation state of catalytic serine affects oxyanion hole formation.
Jurica Novak   +2 more
wiley   +1 more source

Advancing the Identification of Bioactive Molecules and the Construction of a Synergistic Drug Delivery System in Combating Lung Injury

open access: yesAdvanced Science, EarlyView.
Traditional Chinese Medicine (TCM), while holistic and historically esteemed, faces challenges in “miracle cures” due to slow onset, long cycles, and difficulty controlling quality. This study obtains the active ingredients, glabridin (GLA) and puerarin (PUE), from Ge‐Gen Decoction (GGD), developing a safe and effective drug delivery system, GLA‐PUE ...
Jianhong Qi   +7 more
wiley   +1 more source

MaTableGPT: GPT‐Based Table Data Extractor from Materials Science Literature

open access: yesAdvanced Science, EarlyView.
A significant challenge in materials informatics today is the creation of large‐scale experimental databases. This difficulty primarily stems from the complexities involved in consolidating locally distributed datasets from various laboratories into a single cohesive database.
Gyeong Hoon Yi   +11 more
wiley   +1 more source

TIA1‐Mediated Stress Granules Promote the Neuroinflammation and Demyelination in Experimental Autoimmune Encephalomyelitis through Upregulating IL‐31RA Signaling

open access: yesAdvanced Science, EarlyView.
In EAE mice, TIA1 is translocated from the nucleus to the cytoplasm, facilitating SGs formation in neurons. TIA1 knockout in the central nervous system (CNS) of EAE mice yields a notable diminution in neuronal SGs, mitigates CNS inflammatory infiltration, and curtails axonal demyelination.
Xin Hua   +13 more
wiley   +1 more source

The Awakening Brain is Characterized by a Widespread and Spatiotemporally Heterogeneous Increase in High Frequencies

open access: yesAdvanced Science, EarlyView.
This work explores the process of morning awakening of the human brain using polysomnography paired with simultaneous stereo‐electroencephalography, a method that provides high spatial and temporal resolution for examining brain activity. Awakening is characterized by an increase in high‐frequency spectral power and connectivity.
Tamir Avigdor   +5 more
wiley   +1 more source

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