Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
Shade tree diversity, structure, and regeneration dynamics in the Sheko semi-forest coffee agro ecosystem, southwest Ethiopia. [PDF]
Tesfa E, Gudesho G, Wubie M, Awoke A.
europepmc +1 more source
Revealing the Character of Coordination Bonding in 2D Metal–Organic Frameworks
Photoemission‐derived momentum maps and density functional theory calculations show the re‐appearance of frontier molecular orbital patterns at two distinct binding energies, a result of the formation of bonding and antibonding states below the Fermi edge from covalent hybridisation with the metal centres.
Dominik Brandstetter +7 more
wiley +1 more source
EpiMolBio: A novel user-friendly bioinformatic program for genetic variability analysis. [PDF]
Reinosa R +3 more
europepmc +1 more source
Subvoxel Control of Fiber Orientation via Multidirectional Shearing in 3D Printing
A novel 3D printing technique enables subvoxel control of fiber orientation in all three directions through multidirectional shearing using nozzle rotation and inclination. It allows localized and tunable mechanical and thermal responses through programmable microstructures within a strand.
Berin Šeta +5 more
wiley +1 more source
Expanding Clinical and Genetic Landscape of <i>SATB2</i>-Associated Syndrome. [PDF]
Pullano V +14 more
europepmc +1 more source
Newly-recorded species of the genus <i>Atkinsonia</i> Stainton, 1859 (Lepidoptera, Stathmopodidae) from Korea with checklist. [PDF]
Jeong IW, Kim S.
europepmc +1 more source
Digitalizing English-language CT Interpretation for Positive Haemorrhage Evaluation Reporting: the DECIPHER study. [PDF]
Bloom B +8 more
europepmc +1 more source
Strategic Adaptive Management for Transparency, Accountability and Learning: Insights from More Than a Quarter Century of Practice. [PDF]
Roux DJ, Kingsford RT, Cockburn J.
europepmc +1 more source
Criteria used to define appropriate red blood cell transfusion in the perioperative setting: a scoping review. [PDF]
Ivankovic V +6 more
europepmc +1 more source

