Results 101 to 110 of about 8,855,066 (312)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Cognitive Process Frameworks in Academic Writing: A Systematic Review

Indonesian Journal of Educational Research and Review
Academic writing poses significant challenges due to its complex cognitive processes. Research on cognitive processes in academic writing often lacks a clear and coherent theoretical framework, resulting in a fragmented and under-explored understanding ...
Ayyu Subhi Farahiba, Syamsul Sodiq, Titik Indarti, Budinuryanta Yohanes, Mintowati, Didik Nurhadi   +5 more
doaj   +3 more sources

Traumatic Memory and Family Dynamics of Political Prisoners in Leila S. Chudori’s Namaku Alam

Jurnal Poetika
The violent aftermath of Indonesia’s 1965 political upheaval created profound, lasting trauma for politicalprisoners (tahanan politik, or tapol) and their families.
Ahmad Abdul Karim, Natanael Ricky Putra, Nurlina Amiruddin, Agung Rizki Juwi Handoko, Maylia Vinda Ekklesia, Nissa Vidyanita   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Pre-service English teachers’ perceptions of artificial intelligence as pedagogical support during teaching practicum across educational level and frequency of AI use

Cogent Education
Pre-service English teachers (PSETs) perceive artificial intelligence (AI) as pedagogical support potentially helping them manage cognitive load during teaching practicum. However, differences in their perceptions of AI use based on educational level and
Wahyu Diny Sujannah, Pratnyawati Nuridi Suwarso, Frida Unsiah   +2 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Language awareness in language education

, 2009
Ch.9 Investigating the oral fluency of 15 EFL teachers: a quantitative approach revisited Lam, Wendy Y.K.
Berry, Vivien, Berry, Roger, Nunan, David   +2 more
openaire   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source