Results 61 to 70 of about 3,714,812 (309)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Patterns of language choice in the education domain: The Malaysian context [PDF]

open access: yes, 2007
With Malaysia being a multilingual, multicultural and multiracial country, it is not surprising that everyone in Malaysia speaks at least two or more languages.
Abdullah, Ain Nadzimah   +2 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Maintenance of Lampung Language in Padang Cermin District [PDF]

open access: yes, 2018
The aim of this study is to know how far the maintenance and the shift of Lampung language in Padang Cermin district are. Most of Padang Cermin society uses their mother tongue which is Lampung language while their second language is Indonesia Language ...
Wulandari, C. (Citra)
core  

Innovations in Elt Programme Development: Building Strong Foundations with Learner Autonomy [PDF]

open access: yes, 2016
In this paper, I share some experiences about how we, at the National Institute of Education (NIE), Singapore, addressed a challenge with regard to our student teachers\u27 English language standards. This problem, identified by our Ministry of Education,
Alsagoff, L. (Lubna)
core   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Intensive English language program for overseas students at Malaysian private tertiary education institutions [PDF]

open access: yes, 2007
As Malaysia is positioning itself to be a regional center of educational excellence, efforts are taken to recruit international students from other countries in the region to pursue international tertiary education, with English as the language of ...
Nurtjahja, Oktavia R.   +1 more
core  

Teacher-developed materials for the integration of content and language : an action research project in Argentina [PDF]

open access: yes, 2012
This action research project explores the principles that teachers follow when developing their own materials for lessons aimed at integrating content and language in English as a Foreign Language (EFL) lessons in state secondary ...
Banegas, Dario Luis
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Bilingual education and L3 learning: metalinguistic advantage or not? [PDF]

open access: yes, 2015
Metalinguistic skills are highlighted in the literature as providing bilinguals with an advantage in additional language (L3) learning. The extent to which this may apply to bilingual education and content-and-language-integrated-learning settings ...

core   +2 more sources

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