Results 81 to 90 of about 4,440,748 (307)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Computational Linguistics and Adaptation of Turkic Languages to Computer [PDF]

open access: yesUluslararası Uygur Araştırmaları Dergisi, 2017
This article describes computational linguistics briefly, and explains Turkic language studies in this field using Uyghur language as an example. With developing computer technologies, many software has been implemented in order to complete some tasks in
Murat Orhun
doaj  

Netting the maroro : an exploration of Cook Islands teachers' beliefs about language learning and teaching : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Second Language Teaching at Massey University [PDF]

open access: yes, 2003
Teachers' beliefs play an important role in teachers' decision making processes and affect their practice. Beliefs are situated within specific contexts. Little work has been done to investigate the beliefs of language teachers in the South Pacific. This
Edwards, Frances Catherine Edith
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

How are English language teachers supported to develop professional knowledge and practice, within their schools? Qualitative Study [PDF]

open access: yes, 2017
This was a small-scale, qualitative study into the experiences of ‘support in school for improving knowledge and practice of ELT’ amongst teachers participating in a large- scale, quantitative, quasi-experimental (QE) study (EIA, 2017).
Griffiths, Malcolm   +2 more
core  

Critical text analysis : linking language and cultural studies [PDF]

open access: yes, 2010
Many UK universities offer degree programmes in English Language specifically for non-native speakers of English. Such programmes typically include not only language development but also development in various areas of content knowledge. A challenge that
Wharton, Sue
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Application of Functional Magnetic Resonance Imaging in Neurolinguistics: A Systematic Review

open access: yesFrontiers in Biomedical Technologies, 2019
Purpose: This paper aims to review the recent linguistic research carried out with the help of fMRI. Materials and Methods: We performed a comprehensive search on ProQuest and Scopus search engines using keywords: "functional MRI", "fMRI", and ...
Nayereh Joodi, Farzaneh Rahmani
doaj   +1 more source

Exploring the Mental Lexicon of the Multilingual: Vocabulary Size, Cognate Recognition and Lexical Access in the L1, L2 and L3 [PDF]

open access: yes, 2016
Recent empirical findings in the field of Multilingualism have shown that the mental lexicon of a language learner does not consist of separate entities, but rather of an intertwined system where languages can interact with each other (e.g.
Szabo, Cz.
core   +1 more source

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