Results 91 to 100 of about 18,964,040 (350)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Testing English as a foreign language: a case study of classroom tests in Qatar [PDF]

open access: yes, 1991
The thesis is concerned with testing English as a foreign language in general and concentrates on testing in Qatar in particular. Chapter I provides a brief overview of education in Qatar to form a solid basis for the study.
Abbara, Tariq Mustafa
core  

A subset of precise UML for Model-based Testing

open access: yes, 2007
This paper presents an original model-based testing approach that takes a UML behavioural view of the system under test and automatically generates test cases and executable test scripts according to model coverage criteria.
Legeard, B   +19 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Language assessment raters in the call centre industry: Interfaces between language and subject matter experts

open access: yes, 2016
Millions of customer services representatives are assessed each year by subject matter experts (e.g., recruiters, team leaders) in Asian contact centres to ensure good spoken communication skills when serving customers on the phones.
Raquel, MR, Lockwood, JL
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Editorial: Special Issue in Honour of Carol A. Chapelle’s Decades-Long Contributions to Language Testing, Assessment and Learning [PDF]

open access: yes
During her distinguished career, Carol A. Chapelle has made profound contributions to the language testing, assessment and language learning fields. These contributions have significantly shaped the scholarship of applied linguistics, computer-assisted ...
Christine Coombe,Tony Clark,Hassan Mohebbi
core   +1 more source

Editorial – language testing in Asia

open access: yes, 2014
© L p This editorial marks the completion of the third year of publication of Language Testing in Asia, with research articles published from eleven countries including Thailand, Iran, Bhutan, Myanmar, Japan, Oman, India, China, Hong Kong, Macedonia and ...
R. Kirkpatrick
semanticscholar   +1 more source

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