Results 71 to 80 of about 357,445 (310)
South African Journal of Childhood Education, 2017 There is growing evidence of systematic underachievement of South African primary school learners in reading in English as the first additional language.
Brahm Fleisch +2 more
doaj +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Preventive Medicine ReportsObjective: Cigarette smoking differs within the Hispanic population, with adults from Puerto Rico and Cuba (PRC) reporting higher percentages than those from Mexico and Central or South America. Limited research examines if there are similar patterns for
Shichen Zheng +4 more
doaj +1 more source
Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity
Molecular Oncology, EarlyView.Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek +2 more
wiley +1 more source
A STUDY OF INTONATION PATTERNS IN KHASI: LABELING AND ANALYSIS
Journal of the Southeast Asian Linguistics Society, 2023 This paper aims to analyze the intonation patterns found in Khasi, an Austroasiatic language spoken in north-eastern India. The study focuses on the use of pitch and how it correlates with meaning.
Rynjah, Rymphang, Lyngdoh, Saralin
doaj
FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source
The Effect of Context on the L2 Thinking for Speaking Development of Path Gestures
L2 Journal, 2018 Different languages inherently present different thinking for speaking patterns, targeting different meaning components for expression. Previous research has demonstrated that second language learners largely tend transfer their first language thinking ...
Tasha N. Lewis
doaj
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Aspectual se and Telicity in Heritage Spanish Bilinguals: The Effects of Lexical Access, Dominance, Age of Acquisition, and Patterns of Language Use [PDF]
, 2023 Gabriel Martínez Vera +5 more
openalex +1 more source