Results 61 to 70 of about 20,812,150 (281)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Predicting gender-inclusive language use

, 2016
Gender-inclusive language aims at reducing discrimination and exclusion of women by replacing masculine forms, such as policeman with gender-inclusive forms such as police officer, the student, he or she.
Sczesny, Sabine, Moser, Franziska, Wood, Wendy   +2 more
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Multiple Methods for Visualizing Human Language: A Tutorial for Social and Behavioral Scientists

Advances in Methods and Practices in Psychological Science
Humans use language to communicate psychological experiences. Advancements in natural language processing have enabled researchers to quantitatively study and assess psychological states and behaviors through language.
Veerle C. Eijsbroek, August H. Nilsson, Leon Ackermann, Zhuojun Gu, Clara Wiebel, Adithya V. Ganesan, Katarina Kjell, H. Andrew Schwartz, Oscar N. E. Kjell   +8 more
doaj   +1 more source

Integrated Arabic Language Learning in Pesantren: Five Patterns and Their Differential Roles in Developing Kalām and Kitābah

Al-Muyassar
Arabic language instruction is often fragmented across skills and language components, widening the gap between mastery of grammatical rules and productive language use.
Lisa Khillatur Risalah, Muassomah Muassomah, Zakiyah Arifa   +2 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Systematic pattern selection using pattern language grammars and design space analysis [PDF]

Software: Practice and Experience, 2006
AbstractSoftware patterns provide reusable solutions to recurring design problems in a particular context. The software architect or designer must find the relevant patterns and pattern languages that need to be considered, and select the appropriate patterns, as well as the best order to apply them. If the patterns and pattern languages are written by
openaire   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source