Results 91 to 100 of about 1,622,986 (298)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Framing Social Values:\ud An Experimental Study of Culture and Cognition [PDF]

open access: yes, 2007
How and why does a given social value come to shape the way an individual thinks, feels,and acts in a specific social situation? This study links ideas from Goffman’s frame analysis to other lines of research, proposing that dramatic narratives of ...
Stolte, Professor John F.
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

A Corpus-based Multidimensional Analysis of Linguistic Variation in Pakistani Newspapers Columns of Opinion during Covid-19

open access: yesCorporum, 2021
Growing research of language variation has resulted into the recognition of registers or language use in various everyday situations. The present day pandemic of COVID-19 is one of these situations which have affected ...
Muhammad Ijaz, Adnan Tahir, Sajid Ahmed
doaj  

Semantic Variation in Online Communities of Practice [PDF]

open access: yes, 2017
We introduce a framework for quantifying semantic variation of common words in Communities of Practice and in sets of topic-related communities. We show that while some meaning shifts are shared across related communities, others are community-specific ...
Del Tredici, Marco, Fernández, Raquel
core   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

open access: yesMolecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek   +2 more
wiley   +1 more source

A Case Study in RP – Variation and Change in the Pronunciation of King Charles and Prince William

open access: yesJournal of Linguistics and Language Teaching
Received Pronunciation (RP) is the accent traditionally regarded as the model for correct pronunciation in Great Britain. Largely based on the transcriptions set out in Jones’ English Pronouncing Dictionary of 1917, it appears in most current learners ...
Joanna Dornbierer-Stuart
doaj   +1 more source

Le projet RESTAURE, un tremplin pour le picard

open access: yesLa Bretagne Linguistique, 2017
This article relates the work carried out within the framework of the RESTAURE project, which aims to provide computerised resources and automatic processing tools for three regional languages of France, namely Alsatian, Occitan and Picard. In particular,
Fanny Martin
doaj   +1 more source

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