Results 61 to 70 of about 5,743,072 (279)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Emergent sociolinguistic variation in severe language endangerment [PDF]
, 2019 Contrary to Labov’s Principle of style shifting, studies in language obsolescence portray speakers of dying languages as ‘monostylistic’, a characterization questioned here. Variationist methodology is adopted in a context of gradual language death.
Kasstan, J.
core +1 more source
Le bilinguisme sur une radio de service public
La Bretagne Linguistique, 1988 Radio Bretagne Ouest moved to Quimper in the summer of 1982. Thirty jobs were created and the radio station benefited from the technical potential and assistance of Réseau Radio France.
René Abjean
doaj +1 more source
The Politics and Ideologies of Pluricentric German in L2 Teaching
Critical Multilingualism Studies, 2020 Despite a history of rigorous linguistic research on the regional variation of German as well as professional initiatives to promote German, Austrian, and Swiss Standard German as equal varieties, there is still a lack of awareness and systematic ...
Julia Ruck
doaj +2 more sources
Variation as a main feature of norm [PDF]
Trakia Journal of Sciences, 2017 The past half-century has witnessed remarkable growth in the study of language variation, and it has now become a highly productive subfield of research in sociolinguistics.
S. Poladova
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Third language acquisition: Age, proficiency and multilingualism [PDF]
, 2020 This book deals with the phenomenon of third language (L3) acquisition. As a research field, L3 acquisition is established as a branch of multilingualism that is concerned with how multilinguals learn additional languages and the role that their ...
Gudmundson, Anna +9 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source