Results 101 to 110 of about 1,298,540 (325)
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Four Analyses on the Official Letters of Rio Grande do Norte (Brazil) [PDF]
, 2016 Between variation and change, as we know, not only language, but also the texts, with their structures, undergo changes over time. This article aims to analyze textual changes observed in letters of the 18th, 19th and 20th centuries.
Hozanete Alves de Lima, Maria +1 more
core +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Open LinguisticsThe aim of this study is to investigate both quantitatively and qualitatively the impact of career-related major life events (MLEs) on patterns of reported linguistic change across the lifespan, with an emphasis on how individual differences relate to ...
Wirtz Mason A. +2 more
doaj +1 more source
LanguagesThis study evaluates the relationship between language shift and linguistic change in multigenerational immigrant communities, focusing on North American Norwegian (NAmNo) and German heritage varieties.
Alexander K. Lykke, Maike H. Rocker
doaj +1 more source
COMPARATIVE STUDYING OF SOUND MODIFICATION AND THEIR VARIATION IN THE RUSSIAN AND PERSIAN LANGUAGES
Russian Language Studies, 2018 Modern Persian language belongs to Ancient Persian language group. It has 29 phonemes with 6 vowels and 23 consonants. Phoneme changes can be explained on base of vowel and consonant perception.
Alireza Valipur
doaj +1 more source
Italian Occupational Nomenclature [PDF]
, 2017 This paper examines the social and linguistic significance of gendered occupational nouns in Italian. The history of feminism in Italy is important in understanding the effort it took for women to have the rights, in particular the workplace rights, that
Rodgers, Emily
core
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source