Results 71 to 80 of about 1,275,595 (301)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Introduction to the Special Issue: Investigating Language Variation and Change in Portuguese

Languages
This Issue focuses on morphosyntactic variation and change in Portuguese [...]
Patrícia Amaral
doaj   +1 more source

Noun Formation in Pakpak Language [PDF]

, 2015
This study deals with Noun Formation in Pakpak Language. The objectives of thisstudy are to find and describe the noun formation in Pakpak language. Themethod of this research is library research by reading some books related to thisstudy, this research ...
Zainuddin, C. L. (Cinta)
core  

Rhythm and Vowel Quality in Accents of English [PDF]

, 2010
In a sample of 27 speakers of Scottish Standard English two notoriously variable consonantal features are investigated: the contrast of /m/ and /w/ and non-prevocalic /r/, the latter both in terms of its presence or absence and the phonetic form it takes,
D. Abercrombie, E. Hume, F. Ramus, Geoff Schwartz, J. Jenkins, K. Pike, L. Low, L. White, P. Bertinetto, P. Boersma, P. Donegan, P. Wagner, V. Dellwo, W. Strange, W. Strange   +14 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

The propagation of a cultural or biological trait by neutral genetic drift in a subdivided population

, 2007
We study fixation probabilities and times as a consequence of neutral genetic drift in subdivided populations, motivated by a model of the cultural evolutionary process of language change that is described by the same mathematics as the biological ...
Barton, Baxter, ben Avraham, Charlesworth, Cherry, Cox, Crow, Donnelly, Fisher, Gordon, Gradshteyn, Griffiths, Grimmett, Kelly, Kimura, Kingman, Latter, Lieberman, Maruyama, Maruyama, Moran, Möhle, Nagylaki, Nei, Nordborg, Notohara, Notohara, Peliti, R.A. Blythe, Rousset, Rousset, Rousset, Roze, Sjödin, Slatkin, Slatkin, Slatkin, Takahata, Trudgill, Wakeley, Wakeley, Wakeley, Wakeley, Wakeley, Wakeley, Whitlock, Whitlock, Wilkinson-Herbots, Wright   +48 more
core   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

When Positioning Mediates Social Judgements: Life-Stage, Gender, and Yeah-No in Australian English

Languages
This study explores the correlation between social categories and linguistic variables, focusing on the perception of the discourse marker yeah-no in Australian English.
Stacey Sherwood, Robert Mailhammer, Mark Antoniou   +2 more
doaj   +1 more source

German today : an extensive speech data collection in the German speaking area of Europe [PDF]

, 2014
The research project “German Today” aims to determine the amount of regional variation in (near-) standard German spoken by young and older educated adults, and to identify and locate the regional features.
Berend, Nina, Brinckmann, Caren, Kleiner, Stefan, Knöbl, Ralf   +3 more
core