Results 91 to 100 of about 2,399,793 (279)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Second year and running strong
Journal of Lithic Studies, 2015 Welcome to another issue of the Journal of Lithic Studies. This issue in fact marks our second year of publishing. We are definitely pleased with the progress that we have made so far and some of the new ideas that we have tried out.
Otis Norman Crandell
doaj +1 more source
Minority languages of China [PDF]
, 2010 This chapter looks at language endangerment in the People's Republic of China, focusing on three of the main factors that influence language maintenance in China today: increased contact due to population movements and changes in the economy; the ...
LaPolla, Randy J., Poa, Dory
core
Quantum, Stochastic, and Pseudo Stochastic Languages with Few States
, 2014 Stochastic languages are the languages recognized by probabilistic finite automata (PFAs) with cutpoint over the field of real numbers. More general computational models over the same field such as generalized finite automata (GFAs) and quantum finite ...
A. Bertoni +11 more
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
L’« exiguïté » (François Paré, 1992), une notion obsolète ?
GlottopolThis text is a reflection on minorization and future of linguistic and cultural diversity, based on the interview entitled Faire exister les littératures de l’exiguïté (Double ponctuation, Paris, 2021), given to Nathalie Carré by the Canadian academic ...
Christian Lagarde
doaj +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Revista Vasca de Administración Pública, 2009 The level of accomodation of linguistic justifi cations as values that might justify restriction to the Community freedoms and free competition has not found a good answer in European primary law.
Iñigo Urrutia Libarona
doaj +1 more source
Ever Closer Union or Babylonian Discord? [PDF]
, 2007 Extensive multilingualism is one of the most important and fundamental principles of the European Union. However, a large number of official languages (currently 23) hinders communication and imposes substantial financial and legal costs.
Fidrmuc, Jan +2 more
core