Results 81 to 90 of about 1,244,575 (293)

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

The Encyclopaedia of Literature in African Languages [PDF]

, 2012
.wav and .mp3 versions of audio recording of part of the lectureThe Encyclopaedia of Literature in African Languages (ELLAF) project focuses on oral and written literature in African languages.
Baumgardt, Ursula, Lorin, Marie
core   +1 more source

Natural Language Does Not Emerge 'Naturally' in Multi-Agent Dialog

, 2017
A number of recent works have proposed techniques for end-to-end learning of communication protocols among cooperative multi-agent populations, and have simultaneously found the emergence of grounded human-interpretable language in the protocols ...
Batra, Dhruv, Kottur, Satwik, Lee, Stefan, Moura, José M. F.   +3 more
core   +1 more source

Modality-Independent Effects of Phonological Neighborhood Structure on Initial L2 Sign Language Learning [PDF]

, 2015
The goal of the present study was to characterize how neighborhood structure in sign language influences lexical sign acquisition in order to extend our understanding of how the lexicon influences lexical acquisition in both sign and spoken languages.
Bochner, Bochner, Brentari, Brentari, Brooks, Brooks, Carreiras, Carreiras, Caselli, Caselli, Charles, Charles, Charles, Charles, Chen, Chen, De Cara, De Cara, Demke, Demke, Dörnyei, Dörnyei, Fletcher, Fletcher, Garlock, Garlock, Gaskell, Gaskell, Gierut, Gierut, Handshapes, Handshapes, Hanley, Hanley, Hardin, Hardin, Holt, Holt, Joshua Williams, Juffs, Juffs, Krashen, Krashen, Leach, Leach, Lee, Lee, Liddell, Liddell, Luce, Luce, Marentette, Marentette, Mayberry, Mayberry, Mayberry, Mayberry, McLaughlin, McLaughlin, McNeill, McNeill, Meier, Meier, Metsala, Metsala, Morford, Morford, Newport, Newport, Peirce, Peirce, Pichler, Pichler, Rosen, Rosen, Sandler, Sandler, Sharlene D. Newman, Showalter, Showalter, Showalter, Showalter, Slobin, Slobin, Stamer, Stamer, Stoel, Stoel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Storkel, Tamminen, Tamminen, Van, Van, Vitevitch, Vitevitch, Vitevitch, Vitevitch, Williams, Williams, Zamuner, Zamuner   +113 more
core   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Proceedings 2016: Selected papers from the twentieth college-wide conference for students in languages, linguistics & literature [PDF]

, 2017
"Celebrating Voices - past • present • future": Selected papers from the annual college-wide conference for students in languages, linguistics & literature at the College of Languages, Linguistics & Literature, University of Hawai‘i at Mānoa (2016 ...
Camp, Amber, Holden, Daniel
core