Results 51 to 60 of about 110,210 (303)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Iranian EFL Teachers’ Cognition of Corrective Feedback as an Element of Classroom Management: A Qualitative Study [PDF]

open access: yesJournal of Modern Research in English Language Studies
This qualitative study aimed to explore Iranian EFL teachers’ cognition of corrective feedback as one of the elements of classroom management in the EFL context of Iran’s language institutes.
Abbas Ali Rezaee   +2 more
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Can Trust in Climate-Skeptical Governments Inhibit Pro-Environmental Action? Implications for Public Participation and Democratic Innovations

open access: yesSocieties
In the scientific literature, being a woman and citizens’ trust are factors that are often linked to a higher frequency of pro-environmental behaviors.
Mirko Duradoni   +6 more
doaj   +1 more source

Early Soviet research projects and the developments of "Bakhtinian" ideas: the view from the archives [PDF]

open access: yes, 2006
[FIRST PARAGRAPH] When the history of Bakhtin studies is finally written, one particularly ironic aspect that will stand out is that an accurate understanding of the development of dialogic ideas has required us to liberate ourselves from a series of ...
Brandist, C.
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Ideological Struggles and Identity Construction within the Politics of French Linguistics in Indonesia

open access: yesHumaniora, 2019
This article aims to analyse the ideological struggles reflected in the identity construction of French-language users in Indonesia. Using a critical sociolinguistic approach, it examines how Indonesians users, with their ideologies, adapt or adopt the ...
Merry Andriani   +2 more
doaj   +1 more source

Narratives of Arab Anglophone Women and the Articulation of a Major Discourse in a Minor Literature [PDF]

open access: yes, 2014
“It is important to stress that a variety of positions with respect to feminism, nation, religion and identity are to be found in Anglophone Arab women’s writings.
Sarnou, Dalal
core   +3 more sources

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