Results 231 to 240 of about 24,009 (265)

Therapeutic Activity of the Lansoprazole Metabolite 5-Hydroxy Lansoprazole Sulfide in Triple-Negative Breast Cancer by Inhibiting the Enoyl Reductase of Fatty Acid Synthase.

Journal of Medicinal Chemistry, 2022
Fatty acid synthase (FASN), a sole cytosolic enzyme responsible for de-novo lipid synthesis, is overexpressed in cancer but not in normal non-lipogenic tissues. FASN has been targeted, albeit no such inhibitor has been approved.
Jenny Beebe, Sophia Josephraj, Chao J. Wang, Jacob A. Danielson, Qingbin Cui, Caoqinglong Huang, L. Barlow, R. H. Zhang, Tao Zhang, H. Nakshatri, Zizheng Dong, Xiaohong Li, Jing-Yuan Liu, Jian-Ting Zhang   +13 more
semanticscholar   +1 more source

Proton Pump Inhibitor "Lansoprazole" Inhibits Locus Coeruleus's Neuronal Activity and Increases Rapid Eye Movement Sleep.

ACS Chemical Neuroscience, 2021
Alteration of the bodily CO2 concentration and proton pump activity affects the sleep architecture. The brainstem locus coeruleus (LC) area plays an essential role in rapid eye movement (REM) sleep generation and chemoregulation.
F. Mir, Sushil K. Jha
semanticscholar   +1 more source

Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole

Pharmacology, 2020
Introduction: Peptic lesions usually develop when there is an imbalance between aggressive drivers and gastro-protective mediators that guard the lining of the gastrointestinal tract.
M. Abed, F. Alassaf, Mahmood H. M. Jasim, M. Alfahad, M. Qazzaz   +4 more
semanticscholar   +1 more source

Concomitant lansoprazole ameliorates cisplatin‐induced nephrotoxicity by inhibiting renal organic cation transporter 2 in rats

Biopharmaceutics & drug disposition, 2020
Cisplatin is used widely for the treatment of multiple solid tumors. Cisplatin‐induced nephrotoxicity is caused by renal accumulation of cisplatin via human organic cation transporter 2 (hOCT2).
Shun-ichi Hiramatsu, K. Ikemura, Yutaka Fujisawa, T. Iwamoto, M. Okuda   +4 more
semanticscholar   +1 more source

Lansoprazole alleviates pressure overload-induced cardiac hypertrophy and heart failure in mice by blocking the activation of β-catenin.

Cardiovascular Research, 2019
Aims Proton pump inhibitors (PPIs) are widely used in patients receiving percutaneous coronary intervention to prevent gastric bleeding, but whether PPIs are beneficial for the heart is controversial.
Hairuo Lin, Yang Li, Hailin Zhu, Qiancheng Wang, Zhenhuan Chen, Lin Chen, Yingqi Zhu, C. Zheng, Yuegang Wang, W. Liao, J. Bin, M. Kitakaze, Y. Liao   +12 more
semanticscholar   +1 more source

Lansoprazole

Reactions Weekly, 2013
  +7 more sources

Lansoprazole

Reactions Weekly, 2008
  +7 more sources

Experimental Design Approach in the Optimization of Potentiometric Method for Lansoprazole Determination Using Lansoprazole-Tungstate Based Ion-Selective Electrode

Industrial & Engineering Chemistry Research, 2018
The PVC membrane immobilized with lansoprazole-tungstate and plasticized with dioctyl phthalate was characterized by FTIR, XRD, and SEM. The effects of critical parameters such as response time, pH, and temperature on the potential were analyzed, and ...
N. Rahman, S. Khan
semanticscholar   +1 more source

Lansoprazole

Reactions Weekly, 2012
  +5 more sources

Lansoprazole

Reactions Weekly, 2022
openaire   +2 more sources