Results 1 to 10 of about 33,470 (224)

Molecular pathways driving omeprazole nephrotoxicity [PDF]

Redox Biology, 2020
Omeprazole, a proton pump inhibitor used to treat peptic ulcer and gastroesophageal reflux disease, has been associated to chronic kidney disease and acute interstitial nephritis. However, whether omeprazole is toxic to renal cells is unknown. Omeprazole
Maria Dolores Sanchez-Niño, Ana Belén Sanz, Marta Ruiz-Ortega   +2 more
exaly   +4 more sources

Omeprazole as a Novel Treatment Option for Giardiasis in Cats [PDF]

Veterinary Medicine and Science
Background Giardiasis is a common protozoal infection in cats, often treated with nitroimidazole derivatives such as metronidazole and secnidazole. However, there are concerns about resistance to nitroimidazoles and their adverse effects. Recent in vitro
Murat Kaan Durgut, Mahmut Ok, Merve Ider, Amir Naseri, Suleyman Serhat Iyigun, Ayse Evci, Hatice Betul Sahin   +6 more
doaj   +2 more sources

Effects of elagolix on the pharmacokinetics of omeprazole and its metabolites in healthy premenopausal women

Clinical and Translational Science, 2022
This study evaluated the effect of repeated doses of elagolix on the pharmacokinetics (PK) of omeprazole and its metabolites in healthy premenopausal female subjects. Adult premenopausal female subjects (N = 20) received a single oral dose of omeprazole (
Ahmed Nader, Nael M. Mostafa, Elaine Kim, Mohamad Shebley   +3 more
doaj   +1 more source

Omeprazole and lansoprazole enantiomers induce CYP3A4 in human hepatocytes and cell lines via glucocorticoid receptor and pregnane X receptor axis. [PDF]

PLoS ONE, 2014
Benzimidazole drugs lansoprazole and omeprazole are used for treatment of various gastrointestinal pathologies. Both compounds cause drug-drug interactions because they activate aryl hydrocarbon receptor and induce CYP1A genes.
Aneta Novotna, Zdenek Dvorak
doaj   +1 more source

Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect? [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose: To investigate the role of omeprazole and nitrites on the gastric mucosa of rats submitted to specific techniques to induce duodenogastric reflux.
Rosângela Lucinda Rocha Monteiro, Maria Aparecida Marchesan Rodrigues Kobayasi, Marina Rachel de Araujo, Dafny Rocha Monteiro, Nelson Adami Andreollo   +4 more
doaj   +1 more source

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

Heliyon, 2022
Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety.
Harini Sri Rethinavel, Divya Bharathi Selvaraj, Sathya Jeevitha Balakrishnan, Jemi Feiona Vergil Andrews, Jerly Helan Mary Joseph, Mahesh Kandasamy   +5 more
doaj   +1 more source

Reno-protective Role of Ginseng in Counteracting the Long-term Omeprazole Induced Adverse Effects in Albino Rats via Modulation of Inflammation, Apoptosis and Fibrosis [PDF]

Minia Journal of Medical Research, 2023
Background: Omeprazole has long-term use adverse effects even though is commonly used. Aim: Evaluation of the possible renal protective effect of ginseng against the long-term omeprazole-induced adverse effects.
Dina Maher, Nashwa El-Tahawy, Azza Hussien, Ahmed Mahmoud   +3 more
doaj   +1 more source

Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach

Pharmaceutics, 2022
Omeprazole is commonly prescribed to obese patients and patients after laparoscopic sleeve gastrectomy (LSG). The pharmacokinetics of oral omeprazole after LSG are still unknown. Therefore, the aim of this study was to investigate the pharmacokinetics of
Kaifeng Chen, Ping Luo, Shaihong Zhu, Yaqi Lin, Nan Yang, Shuqi Huang, Qin Ding, Liyong Zhu, Qi Pei   +8 more
doaj   +1 more source

Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys

Pharmaceuticals, 2022
The clinical value of colistin, a polymyxin antibiotic, is limited by its nephrotoxicity. Omeprazole is a commonly prescribed proton pump inhibitor.
Mohammed Z. Nasrullah, Khalid Eljaaly, Thikryat Neamatallah, Usama A. Fahmy, Abdulmohsin J. Alamoudi, Hussain T. Bakhsh, Ashraf B. Abdel-Naim   +6 more
doaj   +1 more source

Omeprazole-induced galactorrhea in kidney transplant patients—a case report

Journal of Medical Case Reports, 2022
Background Omeprazole belongs to the pharmacological classifications of proton pump inhibitors and is a widely used medicine. All proton pump inhibitors have a common mechanism of action and are prodrugs that require activation in an acidic environment ...
Choki Dorji, Farruk Ahammed Robin, Kesara Na-Bangchang   +2 more
doaj   +1 more source