Results 11 to 20 of about 34,491 (205)

Omeprazole and adenocarcinoma in the stomach of rats submitted to duodenogastric reflux. Is there a protective effect? [PDF]

Acta Cirúrgica Brasileira, 2020
Purpose: To investigate the role of omeprazole and nitrites on the gastric mucosa of rats submitted to specific techniques to induce duodenogastric reflux.
Rosângela Lucinda Rocha Monteiro, Maria Aparecida Marchesan Rodrigues Kobayasi, Marina Rachel de Araujo, Dafny Rocha Monteiro, Nelson Adami Andreollo   +4 more
doaj   +1 more source

Effect of Obesity and Roux-En-Y Gastric Surgery on Omeprazole Pharmacokinetics [PDF]

, 2022
INTRODUCTION: The prevalence of obesity is increasing globally. The principal aim was to evaluate whether gastric bypass surgery modifies the bioavailability and pharmacokinetic (PK) parameters of omeprazole.
Rubio, Miguel A., Bandrés Moya, Fernando, López Picado, Amanda, Vargas Castrillon, Emilio, Rivas Paterna, Ana Belen, Chicharro, Luis M., López-Picado, Amanda, Portolés-Pérez, Antonio, Paterna, Ana Belén Rivas, Sánchez Pernaute, Andrés, Bandrés, Fernando, Moreno Lopera, Carmen, Castrillón, Emilio Vargas, Portolés Pérez, Antonio, Torres García, Antonio José, Chicharro, Luis M, Rubio, Miguel A   +16 more
core   +1 more source

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

Heliyon, 2022
Omeprazole, a proton pump inhibitor (PPI), has widely been used to treat various gastrointestinal (GI) disorders. Notably, many clinical symptoms of GI disorders have been known to be associated with anxiety.
Harini Sri Rethinavel, Divya Bharathi Selvaraj, Sathya Jeevitha Balakrishnan, Jemi Feiona Vergil Andrews, Jerly Helan Mary Joseph, Mahesh Kandasamy   +5 more
doaj   +1 more source

Reno-protective Role of Ginseng in Counteracting the Long-term Omeprazole Induced Adverse Effects in Albino Rats via Modulation of Inflammation, Apoptosis and Fibrosis [PDF]

Minia Journal of Medical Research, 2023
Background: Omeprazole has long-term use adverse effects even though is commonly used. Aim: Evaluation of the possible renal protective effect of ginseng against the long-term omeprazole-induced adverse effects.
Dina Maher, Nashwa El-Tahawy, Azza Hussien, Ahmed Mahmoud   +3 more
doaj   +1 more source

Effect of Laparoscopic Sleeve Gastrectomy on the Pharmacokinetics of Oral Omeprazole Using a Population Approach

Pharmaceutics, 2022
Omeprazole is commonly prescribed to obese patients and patients after laparoscopic sleeve gastrectomy (LSG). The pharmacokinetics of oral omeprazole after LSG are still unknown. Therefore, the aim of this study was to investigate the pharmacokinetics of
Kaifeng Chen, Ping Luo, Shaihong Zhu, Yaqi Lin, Nan Yang, Shuqi Huang, Qin Ding, Liyong Zhu, Qi Pei   +8 more
doaj   +1 more source

Omeprazole physiological based pharmacokinetics model (PBPK)

, 2021
This repository provides the omeprazole physiological based pharmacokinetics/pharmacodynamics model (PBPK/PD). If you have any questions or problems please open an issue FundingMatthias König is supported by the Federal Ministry of Education and Research
Balci, Sükrü, König, Matthias
core   +1 more source

Omeprazole Prevents Colistin-Induced Nephrotoxicity in Rats: Emphasis on Oxidative Stress, Inflammation, Apoptosis and Colistin Accumulation in Kidneys

Pharmaceuticals, 2022
The clinical value of colistin, a polymyxin antibiotic, is limited by its nephrotoxicity. Omeprazole is a commonly prescribed proton pump inhibitor.
Mohammed Z. Nasrullah, Khalid Eljaaly, Thikryat Neamatallah, Usama A. Fahmy, Abdulmohsin J. Alamoudi, Hussain T. Bakhsh, Ashraf B. Abdel-Naim   +6 more
doaj   +1 more source

Omeprazole-induced galactorrhea in kidney transplant patients—a case report

Journal of Medical Case Reports, 2022
Background Omeprazole belongs to the pharmacological classifications of proton pump inhibitors and is a widely used medicine. All proton pump inhibitors have a common mechanism of action and are prodrugs that require activation in an acidic environment ...
Choki Dorji, Farruk Ahammed Robin, Kesara Na-Bangchang   +2 more
doaj   +1 more source

Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection [PDF]

, 1998
In this randomized, multicenter trial, we evaluated the effectiveness and side effect profile of a modified omeprazole-based triple therapy to cure Helicobacter pylori infection.
Miehlke, Stephan, Bolle, Karl-Heinz, Lehn, Norbert, Höchter, Wilhelm, Klann, Hermann, Krämer, Walter, Simon, Thomas, Stolte, Manfred, Meining, Alexander, Sommer, Albrecht, Bayerdörffer, Ekkehard, Weingart, Josef   +11 more
core   +1 more source

Phase 1 Study of Safety and PK With A Combination of Omeprazole and Trimetazidine for Fatty Acid Oxidation Inhibition in Patients With Advanced Solid Tumors. [PDF]

Clin Transl Sci
ABSTRACT Fatty acid oxidation (FAO) is a metabolic vulnerability in cancer cells, making pharmacologic FAO inhibition a promising therapeutic strategy. This Phase I, open‐label, 3 + 3 dose‐escalation study evaluated the safety, tolerability, pharmacokinetics, and preliminary antitumor activity of two oral FAO inhibitors—omeprazole (KN510), a carnitine ...
Choi W, Chun JW, Sim SH, Han SS, Lee WJ, Kang JH, Kim HC, Lee S, Lee JH, Yoo HJ, Kim SY, Woo SM.   +11 more
europepmc   +2 more sources