Results 11 to 20 of about 76,411 (309)

Molecular pathways driving omeprazole nephrotoxicity

Redox Biology, 2020
Omeprazole, a proton pump inhibitor used to treat peptic ulcer and gastroesophageal reflux disease, has been associated to chronic kidney disease and acute interstitial nephritis. However, whether omeprazole is toxic to renal cells is unknown. Omeprazole
Miguel Fontecha-Barriuso, Diego Martín-Sanchez, Julio M. Martinez-Moreno, Daniela Cardenas-Villacres, Susana Carrasco, Maria D. Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz, Ana B. Sanz   +8 more
doaj   +2 more sources

Omeprazole impairs vascular redox biology and causes xanthine oxidoreductase-mediated endothelial dysfunction

Redox Biology, 2016
Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether ...
Lucas C. Pinheiro, Gustavo H. Oliveira-Paula, Rafael L. Portella, Danielle A. Guimarães, Celio D. de Angelis, Jose E. Tanus-Santos   +5 more
doaj   +2 more sources

Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation

Bioscience Reports, 2021
The curative effect for patients with advanced gastric cancer is still unsatisfactory. Proton pump inhibitors could be a promising treatment strategy that could sensitize gastric cancer cells to antitumor drugs further; however, the underlying molecular ...
S. Feng, G. Qiu, Lihong Yang, Lihua Feng, Xin Fan, Fang Ren, Kaida Huang, Yide Chen   +7 more
semanticscholar   +1 more source

Inhibiting Fatty Acid Synthase with Omeprazole to Improve Efficacy of Neoadjuvant Chemotherapy in Patients with Operable TNBC

Clinical Cancer Research, 2021
Purpose: Fatty acid synthase (FASN) is overexpressed in 70% of operable triple-negative breast cancer (TNBC) and is associated with poor prognosis. Proton pump inhibitors selectively inhibit FASN activity and induce apoptosis in TNBC cell lines. Patients
S. Sardesai, Alexandra Thomas, C. Gallagher, F. Lynce, Y. Ottaviano, T. Ballinger, B. Schneider, A. Storniolo, Amber Bauchle, S. Althouse, S. Perkins, A. Masters, R. Stratford, Zizheng Dong, Jing-Yuan Liu, Jian-Ting Zhang, K. Miller   +16 more
semanticscholar   +1 more source

Omeprazole use and risk of chronic kidney disease evolution

PLoS ONE, 2020
Rationale, aims and objectives In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide.
J. V. M. Guedes, J. A. Aquino, Tássia Lima Bernardino Castro, Flávio Augusto de Morais, A. Baldoni, V. S. Belo, Alba Otoni   +6 more
semanticscholar   +1 more source

Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection [PDF]

, 1998
In this randomized, multicenter trial, we evaluated the effectiveness and side effect profile of a modified omeprazole-based triple therapy to cure Helicobacter pylori infection.
Bayerdörffer, Ekkehard, Bolle, Karl-Heinz, Höchter, Wilhelm, Klann, Hermann, Krämer, Walter, Lehn, Norbert, Meining, Alexander, Miehlke, Stephan, Simon, Thomas, Sommer, Albrecht, Stolte, Manfred, Weingart, Josef   +11 more
core   +1 more source

Prevalence of Gastroesophageal Reflux in Cats During Anesthesia and Effect of Omeprazole on Gastric pH. [PDF]

, 2017
BackgroundGastroesophageal reflux (GER) is poorly characterized in anesthetized cats, but can cause aspiration pneumonia, esophagitis, and esophageal stricture formation.ObjectiveTo determine whether pre-anesthetic orally administered omeprazole ...
Belafsky, PC, Della Maggiore, A, Fulton, A, Garcia, RS, Marks, SL, Osborn, JM, Pierce, T, Pypendop, BH, Walker, VJ   +8 more
core   +3 more sources

Degradation of lansoprazole and omeprazole in the aquatic environment [PDF]

, 2006
Lansoprazole and omeprazole degrade in water leading to sulfides, benzimidazolones and a red complex material. Degradation is accelerated in acid medium and by solar simulator irradiation.
BRIGANTE M., DELLA GRECA, MARINA, IESCE, MARIA ROSARIA, PREVITERA, LUCIO, RUBINO, MARIA, TEMUSSI, FABIO   +5 more
core   +1 more source

Randomised, double-blind, placebo-controlled pilot trial of omeprazole in idiopathic pulmonary fibrosis

Thorax, 2019
Background Cough is a common, disabling symptom of idiopathic pulmonary fibrosis (IPF), which may be exacerbated by acid reflux. Inhibiting gastric acid secretion could potentially reduce cough.
P. Dutta, W. Funston, H. Mossop, Vicky Ryan, Rhys T Jones, Rebecca Forbes, S. Sen, J. Pearson, S. Griffin, J. Smith, Christopher Ward, Ian A. Forrest, A. Simpson   +12 more
semanticscholar   +1 more source

Science-in-brief: Clinical highlights from BEVA Congress 2016 [PDF]

, 2017
No abstract ...
Chauché, C., Kennedy, R.
core   +1 more source