Results 31 to 40 of about 76,411 (309)

Molecular mechanism of inhibition of the mitochondrial carnitine/acylcarnitine transporter by omeprazole revealed by proteoliposome assay, mutagenesis and bioinformatics. [PDF]

PLoS ONE, 2013
The effect of omeprazole on the mitochondrial carnitine/acylcarnitine transporter has been studied in proteoliposomes. Externally added omeprazole inhibited the carnitine/carnitine antiport catalysed by the transporter.
Annamaria Tonazzi, Ivano Eberini, Cesare Indiveri   +2 more
doaj   +1 more source

Effects of astragaloside IV on the pharmacokinetics of omeprazole in rats

Pharmaceutical Biology, 2019
Context: Omeprazole and astragaloside IV (AS-IV) are widely used for the treatment of gastric ulcers in China clinics. Objective: This study investigates the effects of AS-IV on the pharmacokinetics of omeprazole in rats.
Wei Liu, Guozhi Liu, Jing Liu
doaj   +1 more source

The association of increased stomach wall radiotracer uptake with prolonged use of Omeprazole capsules on myocardial perfusion imaging (MPI) using 99mTc-sestamibi SPECT [PDF]

, 2013
Myocardial perfusion imaging (MPI) is widely used in routine practice for diagnosis and risk stratification of coronary artery disease (CAD). Intense curvilinear activity in the stomach wall of a patient was seen on MPI raw data.
Abbaszadeh, M., Assadi, M., Jallalat, S., Javadi, H., Mogharrabi, M., Nabipour, I., Semnani, S., Tabib, S.M.   +7 more
core   +1 more source

In vivo and in vitro protective effects of omeprazole against neuropathic pain

Scientific Reports, 2016
Apart from reducing the acid secretion, omeprazole inhibits activation of the nuclear factor-κB, release of inflammatory cytokines and chemotaxis of neutrophils. These mechanisms prompted us to evaluate antineuropathic effect of omeprazole in the chronic
Sanjay K. Chanchal, U. Mahajan, S. Siddharth, N. Reddy, S. Goyal, P. Patil, B. Bommanahalli, C. Kundu, Chandragouda R. Patil, S. Ojha   +9 more
semanticscholar   +1 more source

Changes in omeprazole pharmacokinetics in rats with diabetes induced by alloxan or streptozotocin: Faster clearance of omeprazole due to induction of hepatic CYP1A2 and 3A1

Journal of Pharmacy & Pharmaceutical Sciences, 2007
Purpose. To investigate the effect of diabetes mellitus induced by alloxan (DMIA) or streptozotocin (DMIS) on the pharmacokinetics of omeprazole in rats.
Dae Young Lee, Myung G. Lee, Hyun Sook Shin, Inchul Lee   +3 more
doaj   +1 more source

Impact of fresh grape juice on the pharmacokinetics of omeprazole: results of a food–drug interaction study

Frontiers in Pharmacology
Grapes have been widely used for dietary ailments due to their attributed pharmacological activities. Resveratrol, the chief constituent of grapes, is responsible for their pharmacological benefits.
Tayyaba Iftikhar, Zafar Iqbal, Yasar Shah, Nauman Rahim Khan, Muhammad Abbas, Omer Shehzad, Fazal Hadi, Haseeba Sardar, Ali Abusharha, Maria Daglia, Maria Daglia, Haroon Khan, Haroon Khan   +12 more
doaj   +1 more source

Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH

BMC Gastroenterology, 2012
Background The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms.
Iida Hiroshi, Inamori Masahiko, Fujii Tetsuro, Sekino Yusuke, Endo Hiroki, Hosono Kunihiro, Nonaka Takashi, Koide Tomoko, Takahashi Hirokazu, Yoneda Masato, Goto Ayumu, Abe Yasunobu, Kobayashi Noritoshi, Kirikoshi Hiroyuki, Kubota Kensuke, Saito Satoru, Gotoh Eiji, Maeda Shin, Nakajima Atsushi   +18 more
doaj   +1 more source

Binding of omeprazole to protein targets identified by monoclonal antibodies.

PLoS ONE, 2020
Omeprazole is the most commonly used proton pump inhibitor (PPI), a class of medications whose therapeutic mechanism of action involves formation of a disulfide linkage to cysteine residues in the H+/K+ ATPase pump on gastric secretory cells.
Naw May Pearl Cartee, Michael M Wang
doaj   +2 more sources

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source

Omeprazole and Risk of Hypertension: Analysis of Existing Literature and the WHO Global Pharmacovigilance Database

Drugs - Real World Outcomes
Introduction The association between omeprazole and hypertension is poorly documented. The summary of product characteristics of omeprazole approved by major regulators did not mention hypertension as an adverse drug event.
Merhawi Bahta, Natnael Russom, Amon Solomon Ghebrenegus, Yohana Tecleab Okubamichael, Mulugeta Russom   +4 more
doaj   +1 more source