Results 101 to 110 of about 145,859 (268)

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure

Clinical Pharmacology &Therapeutics, EarlyView.
This study investigated genetic determinants of the pharmacokinetics of the CYP2C8 index drugs repaglinide and gemfibrozil, and their interaction in healthy participants. Sequencing data from a study with montelukast revealed a novel functional CYP2C8 allele (rs2071426, CYP2C8*19), predicted to create an intronic splice donor site.
Anssi J. H. Mykkänen, Päivi Hirvensalo, Kathrin Klein, Dorota Kaminska, Markus Grube, Tuija Tapaninen, Johanna I. Kiiski, Mikko Neuvonen, Ville T. Männistö, Jussi Pihlajamäki, Mladen Tzvetkov, Matthias Schwab, Aleksi Tornio, Janne T. Backman, Mikko Niemi   +14 more
wiley   +1 more source

Fatalities within seven days after equine standing sedation: A prospective, multicentre study

Equine Veterinary Journal, EarlyView.
Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla, José I. Redondo, Polly M. Taylor, Luis Domenech, Javier Doménech, Gordon Mark Johnston, Regula Bettschart‐Wolfensberger   +6 more
wiley   +1 more source

Single stage laparoscopic cholecystectomy with intraoperative endoscopic retrograde cholangiopancreatography for cholecysto-choledocholithiasis. Lesson learnt from the COVID-19 pandemic

Frontiers in Surgery
IntroductionCholedocholithiasis, a common complication of gallstone disease, poses significant risks including cholangitis and pancreatitis. Various treatment approaches exist, including single-stage and two-stage techniques, with recent literature ...
Martino Gerosa, Angelo Guttadauro, Domenico Francesco Stillittano, Richard Sassun, Annaclara Sileo, Barbara Vignati, Emanuele Di Fratta, Dario Maggioni, Giulio Mari   +8 more
doaj   +1 more source

Reimbursement Design and Procedure‐Level Gross Profit of Robot‐Assisted Gastrectomy in a Publicly Financed Health System: Evidence From Japan

The International Journal of Health Planning and Management, EarlyView.
ABSTRACT Publicly financed healthcare systems must balance technological innovation with fiscal constraints. Reimbursement mechanisms influence institutional decisions regarding the adoption of high‐cost surgical technologies. This study evaluated whether current reimbursement designs adequately reflect procedure‐level gross surgical profit of robot ...
Yoshimasa Akashi, Koichi Ogawa, Yohei Owada, Tsuyoshi Enomoto, Kinji Furuya, Kazuhiro Takahashi, Osamu Shimomura, Yoshihiro Miyazaki, Tatsuya Oda   +8 more
wiley   +1 more source

A rare case of perineal neuralgia treated with ultrasound‐guided nerve block combined with water separation

Ibrain, Volume 11, Issue 1, Page 106-111, Spring 2025.
A middle‐aged man presented with a right indirect inguinal hernia in November 2020 and underwent laparoscopic high ligation of the right hernial sac. Intermittent acupuncture‐like pain in the skin of the right scrotum and medial thigh occurred 1 month after surgery and lasted for 6 months. Under ultrasound guidance, ilioinguinal nerve and genitofemoral
Yong Wang, Min Wang, Rui Jiang, Zhao‐Qiong Zhu, Guang‐Cai Li   +4 more
wiley   +1 more source

Association Between Socioeconomic Position and Diagnosis, Treatment and Survival of Patients With Stage I–III Rectal Cancer in the Netherlands

International Journal of Cancer, EarlyView.
ABSTRACT Socioeconomic position (SEP) influences cancer care and outcomes, even in countries with government‐funded healthcare. This population‐based study examined associations between SEP, rectal cancer care and survival of patients in the Netherlands.
Suzanne E. N. de Vries, Felice N. van Erning, Mieke J. Aarts, Alice M. Couwenberg, Laskarina J. K. Galanos, Irene E. G. van Hellemond, Ignace H. J. T. de Hingh, Robin Lurvink, Iris D. Nagtegaal, Johannes H. W. de Wilt, Marloes A. G. Elferink   +10 more
wiley   +1 more source

Spontaneous hemoperitoneum in a 29‐week pregnancy with a history of endometriosis: A case report and review of the literature

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 31-37, April 2025.
Abstract Spontaneous hemoperitoneum in pregnancy (SHIP) is defined as sudden, nontraumatic intraperitoneal bleeding that occurs during pregnancy or up to 42 days postpartum. The incidence ranges between 4 and 4.9 per 100 000 births. Although seen rarely, it is associated with perinatal morbidity and mortality due to maternal hemodynamic instability ...
Shamsi Mehdiyev, Fatma Basak Tanoglu, Esma Demir Altuncu, Engin Oral   +3 more
wiley   +1 more source

Anti‐NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 23-30, April 2025.
Abstract Autoimmune encephalitis is a group of disorders characterized by symptoms of dysfunction of the limbic and extra‐limbic systems that occur in association with antibodies against intracellular antigens, synapses, or proteins located on the surface of nerve cells. Anti‐NMDA (N‐methyl‐D‐aspartate) receptor encephalitis was first described in 2007
Pham Ba Nha, Nguyen Phuong Tu, Nguyen Viet Ha, Duong Thi Thu Hien, Nguyen Thi Thu Phuong, Nguyen Anh Son, Nguyen Tien Hoang   +6 more
wiley   +1 more source

53BP1-independent Shieldin-BRCA1 antagonism at replication-coupled double-strand breaks

Nature Communications
BRCA1-deficient tumors are hypersensitive to PARP inhibitors (PARPi) due to impaired homologous recombination (HR). The 53BP1-Shieldin complex inhibits end resection at replication-independent DNA double-strand breaks (DSBs), promoting PARPi sensitivity ...
Yi-Li Feng, Meng Wang, Ge Li, Ruo-Dan Chen, Rui Yao, Shun-Li Dong, Xiu-Jun Cai, An-Yong Xie   +7 more
doaj   +1 more source

A Novel MPT‐Driven Necrosis‐Related lncRNA Signature for Prognostic Prediction in Hepatocellular Carcinoma: Validation Using Organoids

Cancer Medicine
Background Mitochondrial permeability transition (MPT)‐driven necrosis, a recently identified form of programmed cell death, significantly influences tumor progression, therapy response, and prognosis.
Yang Liu, Liye Tao, Zefeng Shen, Junhao Zheng, Yali Wang, Meijie Chen, Yangyang Xie, Hongjun Chen, Jingwei Cai, Haoyu Pan, Shihao Li, Renan Jin, Junjie Xu, Xiao Liang   +13 more
doaj   +1 more source