Results 171 to 180 of about 216,973 (262)

Transforming Fragile Hydrogel Chips Into Standardized Cartridges via Contact Line Pinning for Robust Microfluidics

open access: yesSmall, EarlyView.
Hydrogel‐based microfluidic chips revolutionize drug delivery, tissue engineering, and biosensing, yet face challenges due to fragility and connection difficulty. This study introduces a novel cartridge design that enhances usability through a hydrogel–plastic hybrid design and a contactless connection method.
Sin‐Yung Siu   +8 more
wiley   +1 more source

Evidence for Drop‐Like Nuclear Deformation in Sheared Endothelial Monolayers

open access: yesSmall, EarlyView.
Physiological shear stress smoothens endothelial monolayers by selectively eliminating less‐spread cells with tall, wrinkled nuclei. Nuclear volume and surface area remain constant, consistent with drop‐like deformation governed by geometric constraints.
Mohammad Mohajeri   +7 more
wiley   +1 more source

Precision mRNA Delivery via Ultrasound‐Controlled Release Perfluorocarbon Emulsions: An Innovative Ultrasound Theranostic Strategy with 19F MRI Feasibility

open access: yesSmall, EarlyView.
A key challenge in advancing messenger RNA (mRNA) therapeutics in cardiovascular diseases lies in achieving controlled release at the precise site within the vasculature. This study presents the development of perfluorocarbon nanodroplets with exceptional theranostic potential, enabling real‐time tracking through ultrasound and fluorine‐19 (19F ...
Haikun Liu   +14 more
wiley   +1 more source

Aggressive Glioblastoma Cells Enhance the Migratory Persistence and Velocity of Less Aggressive Cells to Promote Tumor Dissemination

open access: yesSmall, EarlyView.
We identify biophysical motility parameters explaining how less aggressive EGFRwt‐overexpressing Glioblastoma cells become more infiltrative when influenced by aggressive EGFRvIII‐expressing cells. Using bulk assays and microfluidic chips, we show that EGFRvIII cells enhance velocity and persistence in EGFRwt cells via Src‐mediated communication ...
Fatima‐ezzahra Ait Mohand   +5 more
wiley   +1 more source

Topography‐Free Dual‐Lubricant Patterned Slippery Surfaces for Programmable Droplet Control and High‐Performance Water Harvesting

open access: yesSmall, EarlyView.
A patterned dual‐lubricant SLIPS creates interfacial energy asymmetry, guiding droplet migration without external actuation. Condensed droplets formed on the fluorinated‐oil‐infused regions migrate to the silicone‐oil‐infused domains, where rapid growth and coalescence occur.
Jinchul Yang   +11 more
wiley   +1 more source

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