Results 41 to 50 of about 4,293 (239)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Research and application of high-level directional drilling holes in gas extraction lap part

Meikuang Anquan
The reasonable lap of high-level directional drilling holes in adjacent drilling sites is an important link to ensure the stable extraction effect and improve the effective utilization rate of drilling holes.
Mingjie ZHANG, Wenbo DENG, Zhihong TAN, Xuze LI, Cao LIU, Shuai YUAN   +5 more
doaj   +1 more source

Feasibility of Reduced Lap‐Spliced Length in Polyethylene Fiber‐Reinforced Strain‐Hardening Cementitious Composite [PDF]

Advances in Materials Science and Engineering, 2018
This research investigates the interfacial behavior between polyethylene (PE) fiber‐reinforced strain‐hardening cement composite (PE‐SHCC) and reinforcing bars that are spliced in the tension region to determine feasibility of reduced lap‐spliced length in PE‐SHCC. Twenty test specimens were subjected to monotonic and cyclic tension loads.
Wonchang Choi, Seok-Joon Jang, Hyun-Do Yun   +2 more
openaire   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Combined mechanical couplers and special-length-priority algorithm for reducing rebar consumption and cutting waste of beam reinforcement

Results in Engineering
The surging demand for reinforced concrete buildings has led to excessive consumption of rebars, resulting in substantial rebar-cutting waste and greenhouse gas emissions. Various approaches have been explored to mitigate this issue, including lap-splice
Daniel Darma Widjaja, Chang-Young Park, Chang-Ho Choi, Sunkuk Kim   +3 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Multivariate Studies of Bulb Yield and Morphological Characters in Garlic (Allium sativum L.) Genotypes at Kulumsa, Southeastern Part of Ethiopia

International Journal of Bio-Resource and Stress Management
The experiment was carried out for two consecutive years (2020–2021) from June to October at Kulumsa Agricultural Research Center, Assella, Ethiopia under rain fed conditions using an Alpha lattice design with two replications. One hundred twenty Garlic
Dasta Tsagaye, Nimona Fufa, Gizaw Wegayehu, Demis Fikre, Awoke Ali   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Inadequate Lap Length Improvement in Precast Concrete Beams Connections

IOSR Journal of Mechanical and Civil Engineering, 2016
The motivation behind this research is to provide a method to improve the beam to beam connection of precast concrete with inadequate lap length. The methodology of this research divided into two Parts. In the first Part, the paper tests six beam to beam connections. This was considered the preliminary findings of the study.
openaire   +1 more source