Results 81 to 90 of about 4,423 (273)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Overlapping Length and Lifetime Influence on Load of Simple Over-lapped Adhesive Bond

Transactions of the VŠB - Technical University of Ostrava, Mechanical Series, 2011
A production process is various in single industrial branches; it usually has one common element – bonding pieces of material. We can say on the base of the production sphere analysis that simple overlapped adhesive bonds are the most common adhesive bonding technology application. The research publicated in this paper deals with then too.
Miroslav MÜLLER, Josef ŽARNOVSKÝ, Jiří FRIES   +2 more
openaire   +2 more sources

The effect of shear and lap arrangement on reinforcement lap strength [PDF]

, 2017
The paper is concerned with the design of tension laps in reinforced concrete structures. The most recent design recommendations for laps are found in fib Model Code 2010 which is likely to influence the next revision of EN-1992. This is of concern to UK
Micallef, M, Robert Vollum, Vollum, RL, Marianna Micallef   +3 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

The behaviour of sleeve connection with spiral reinforcement and additional longitudinal bar under direct tensile load [PDF]

, 2009
One of the important precast concepts is all the precast elements must be connected for the stability. Therefore, the connection systems of the precast concrete structure must be designed in such a way that its structural performance is equivalent to ...
Manap, Norliana
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Monitoring the crack lengths in composite lap joints under cyclic loading

Journal of Mechanics
ABSTRACT Monitoring crack lengths in composites lap joints is crucial for the evaluation of safety and integrity in composite structures. The crack lengths in adhesively bonded single-lap and double-strap joints were characterized by using epoxy adhesive containing aligned graphene.
Cheng-Che Lai, Po-Chun Chuang, Jia-Lin Tsai   +2 more
openaire   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Local Bond Strength based Lap Splice Length Model of Reinforcing Bars [PDF]

Second International Conference on Advances in Civil, Structural and Mechanical Engineering - ACSM 2015, 2015
Lap splice is a critical issue in the structural performance of Reinforced Concrete members. In the present study, the lap splice length of rebars was theoretically studied. On the basis of the bond behavior in the lap splice, a simplified design method was developed to predict the lap splice length of rebars under tension force. In the proposed method,
openaire   +1 more source

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source