Results 181 to 190 of about 144,814 (257)

The Endothelial CXCR Family in Vascular Health and Disease

open access: yesiNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu   +4 more
wiley   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

open access: yesiNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong   +5 more
wiley   +1 more source

Ultrasound–triggered tumor‐selective nitric oxide release enhances tumor penetration of antibody–conjugated nanomedicine

open access: yesInterdisciplinary Medicine, EarlyView.
Ultrasound‐triggered nitric oxide release from S‐nitrosated hyaluronic acid (HA‐SNO) induces tumor vasodilation and disrupts the vascular barrier, potently enhancing the intratumoral penetration of antibody‐conjugated nanomedicines. Abstract The tumor vascular barrier restricts the penetration of antibody‐conjugated nanomedicine, severely limiting its ...
Xiaodong Wang   +4 more
wiley   +1 more source

Microelectromechanical system‐based devices for the diagnosis, treatment, and monitoring of ophthalmic diseases

open access: yesInterdisciplinary Medicine, EarlyView.
Due to the characteristics of miniaturization, high sensing performance, integration, and high comfort, MEMS‐based devices were employed to design sensors, imaging systems, drug delivery systems, retinal prosthesis, surgical tools, and wearable products for the ophthalmic disease diagnosis, treatment, and monitoring.
Yaling Peng   +10 more
wiley   +1 more source

Implantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary

open access: yesInterdisciplinary Medicine, EarlyView.
This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.
Yu Zeng   +9 more
wiley   +1 more source

Transcranial Color‐Coded Duplex Sonography in Large‐Vessel Vasculitis Compatible With Takayasu Arteritis Presenting Intracranial Involvement and Vertebrobasilar Dolichoectasia: A Case Report

open access: yesJournal of Clinical Ultrasound, EarlyView.
This case illustrates sequential intracranial occlusions in large‐vessel vasculitis compatible with Takayasu arteritis preserving perfusion through robust collateral pathways. Transcranial color‐coded duplex sonography identified characteristic blunted flow patterns and focal turbulence, underscoring its value in detecting hemodynamic compromise beyond
Maria Júnia Lira e Silva   +4 more
wiley   +1 more source

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