Results 11 to 20 of about 3,266,852 (276)
Anaplastic large cell lymphoma [PDF]
Archive of Oncology, 2006 Anaplastic large cell lymphoma is defined by a proliferation of large pleomorphic blasts and a constant expression of the CD30 molecule on all neoplastic cells, and has been clinically subdivided into a primary form and a secondary form.
Tiodorović Jelica +4 more
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Mini-PE, a prime editor with compact Cas9 and truncated reverse transcriptase
Molecular Therapy: Nucleic Acids, 2023 Prime editor (PE) is a versatile genome editing tool that does not need extra DNA donors or inducing double-strand breaks. However, in vivo implementation of PE remains a challenge because of its oversized composition.
Ting Lan +14 more
doaj +1 more source
The role of extracellular vesicles in animal reproduction and diseases
Journal of Animal Science and Biotechnology, 2022 Extracellular vesicles (EVs) are nanosized membrane-enclosed compartments that serve as messengers in cell-to-cell communication, both in normal physiology and in pathological conditions.
Sangiliyandi Gurunathan +4 more
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Molecular Therapy: Methods & Clinical Development, 2022 Pluripotent stem cells (PSCs) are promising in regenerative medicine. A major challenge of PSC therapy is the risk of teratoma formation because of the contamination of undifferentiated stem cells. Constitutive promoters or endogenous SOX2 promoters have
Yang Liu +15 more
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Breast metastasis and lung large-cell neuroendocrine carcinoma: first clinical observation [PDF]
, 2017 The lung Large-cell neuroendocrine carcinoma (LCNEC) is a very rare aggressive neuroendocrine tumor with a high propensy to metastasize and very poor prognosis.
Di Cristofano, C +8 more
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Generation of a homozygous RANGRF knockout hiPSC line by CRISPR/Cas9 system
Stem Cell Research, 2023 The RAN Guanine Nucleotide Release Factor (RANGRF) gene encodes the protein MOG1, which binds to Nav1.5 and facilitates its transport to the cell membrane. Nav1.5 mutations have been linked to various cardiac arrhythmias and cardiomyopathy.
Meiling Jiang +7 more
doaj +1 more source
Annals of Oncology, 2006 Rituximab has greatly improved standard cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) chemotherapy, but prospects remain poor in patients with adverse risk factors. We need to know whether the addition of rituximab also improves the efficacy of more intensive treatments and how to use molecular profiling to guide us in introducing ...
C, Gisselbrecht, N, Mounier
openaire +2 more sources
Quantitative imaging of the collective cell movements shaping an embryo [PDF]
, 2009 The recent development of imaging and image processing techniques, such as 4D microscopy and 3D cell tracking, enables analysis through quantification of the movement of large cell populations in vivo.
Fraser, Scott E. +3 more
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, 2009 We investigate methods for modelling metabolism within populations of cells. Typically one represents the interaction of a cloned population of cells with their environment as though it were one large cell. The question is as to whether any dynamics are
Kieran Smallbone
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Rare Tumors, 2016 The prognosis of the primary refractory anaplastic lymphoma kinase (ALK+) anaplastic T large cell lymphoma is ominous. The identification of molecular targets with potential to drive oncogenesis remains a cornerstone for the designing of new selective ...
Carolina Valeria Mahuad +5 more
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