Results 11 to 20 of about 14,848,284 (309)

Long-term disease-free survivor of metastatic large-cell neuroendocrine carcinoma of the lung treated with amrubicin and irinotecan

Drug Design, Development and Therapy, 2009
Shinichiro Ryuge1, Shi-Xu Jiang2, Mayuko Wada1, Ken Katono1, Maiko Iwasaki1, Akira Takakura1, Sakiko Otani1, Yuka Kimura1, Tomoya Fukui1, Masanori Yokoba1, Masaru Kubota1, Masato Katagiri1, Kazusige Hayakawa3, Noriyuki Masuda11Department of Respiratory ...
Shinichiro Ryuge, Shi-Xu Jiang, Mayuko Wada, Ken Katono, et al.   +4 more
doaj   +1 more source

Discovery of novel molecular and biochemical predictors of response and outcome in diffuse large B-cell lymphoma [PDF]

, 2009
PhDDiscovery of Novel Molecular and Biochemical Predictors of Response and Outcome in Diffuse Large B-cell Lymphoma Diffuse large B-cell lymphoma (DLBCL) is the commonest form of non-Hodgkin lymphoma and responds to treatment with a 5-year overall ...
Last, Kim William
core   +4 more sources

Inducible caspase-9 suicide gene under control of endogenous oct4 to safeguard mouse and human pluripotent stem cell therapy

Molecular Therapy: Methods & Clinical Development, 2022
Pluripotent stem cells (PSCs) are promising in regenerative medicine. A major challenge of PSC therapy is the risk of teratoma formation because of the contamination of undifferentiated stem cells. Constitutive promoters or endogenous SOX2 promoters have
Yang Liu, Yang Yang, Yangyang Suo, Chuan Li, Min Chen, Shuwen Zheng, Hao Li, Chengcheng Tang, Nana Fan, Ting Lan, Jizeng Zhou, Yingying Li, Jiaowei Wang, Huangyao Chen, Qingjian Zou, Liangxue Lai   +15 more
doaj   +1 more source

Anaplastic Large Cell Lymphoma [PDF]

American Journal of Clinical Pathology, 2007
Session 8 of the 2005 Society of Hematopathology/European Association for Haematopathology Workshop was devoted to anaplastic large cell lymphoma (ALCL). Most cases submitted were anaplastic lymphoma kinase (ALK)+ ALCL highlighting unusual clinical settings, histologic variants, and variant translocation partners.
L Jeffrey, Medeiros, Kojo S J, Elenitoba-Johnson   +1 more
openaire   +2 more sources

Generation of a homozygous RANGRF knockout hiPSC line by CRISPR/Cas9 system

Stem Cell Research, 2023
The RAN Guanine Nucleotide Release Factor (RANGRF) gene encodes the protein MOG1, which binds to Nav1.5 and facilitates its transport to the cell membrane. Nav1.5 mutations have been linked to various cardiac arrhythmias and cardiomyopathy.
Meiling Jiang, Chengcheng Tang, Xian Luo, Xiaoqing Zhou, Min Chen, Yue Chi, Liangxue Lai, Qingjian Zou   +7 more
doaj   +1 more source

Three years sustained complete remission achieved in a primary refractory ALK-positive anaplastic T large cell lymphoma treated with crizotinib

Rare Tumors, 2016
The prognosis of the primary refractory anaplastic lymphoma kinase (ALK+) anaplastic T large cell lymphoma is ominous. The identification of molecular targets with potential to drive oncogenesis remains a cornerstone for the designing of new selective ...
Carolina Valeria Mahuad, Maria de los Ángeles Vicente Repáraz, Marta E. Zerga, María Florencia Aizpurúa, Claudia Casali, Gonzalo Garate   +5 more
doaj   +1 more source

Cell Migration with Multiple Pseudopodia: Temporal and Spatial Sensing Models [PDF]

, 2013
Cell migration triggered by pseudopodia (or “false feet”) is the most used method of locomotion. A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical aspects of the biological phenomenon.
ALLENA, Rachele
core   +1 more source

Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis

IUCrJ, 2021
Cofactor-independent urate oxidase (UOX) is an ∼137 kDa tetrameric enzyme essential for uric acid (UA) catabolism in many organisms. UA is first oxidized by O2 to dehydroisourate (DHU) via a peroxo intermediate.
Lindsay McGregor, Tamás Földes, Soi Bui, Martine Moulin, Nicolas Coquelle, Matthew P. Blakeley, Edina Rosta, Roberto A. Steiner   +7 more
doaj   +1 more source

Chemotaxis: a feedback-based computational model robustly predicts multiple aspects of real cell behaviour [PDF]

, 2011
The mechanism of eukaryotic chemotaxis remains unclear despite intensive study. The most frequently described mechanism acts through attractants causing actin polymerization, in turn leading to pseudopod formation and cell movement.
Haastert, Peter J.M. van,, Peter J M van Haastert, van Haastert, Peter J. M., van Haastert, Peter J.M., Matthew P. Neilson, Douwe M Veltman, Webb, Steven D., Insall, Robert H., Webb, Steven D.,, Neilson, Matthew P.,, Neilson, Matthew P., Matthew P Neilson, Douwe M. Veltman, Peter J. M. van Haastert, Insall, Robert H.,, Steven D Webb, Webb, Steven, Robert H Insall, John A. Mackenzie, Mackenzie, John A.,, John A Mackenzie, Veltman, Douwe M.,, Mackenzie, John A., Veltmahn, Douwe M., Veltman, Douwe M., Steven D. Webb, Robert H. Insall   +26 more
core   +5 more sources

Fostering landscape immunity to protect human health: A science‐based rationale for shifting conservation policy paradigms

Conservation Letters, 2022
Anthropogenic land use change is a major driver of zoonotic pathogen spillover from wildlife to humans. According to the land use‐induced spillover model, land use change alters environmental conditions that in turn alter the dynamics between zoonotic ...
Jamie K. Reaser, Brooklin E. Hunt, Manuel Ruiz‐Aravena, Gary M. Tabor, Jonathan A. Patz, Daniel J. Becker, Harvey Locke, Peter J. Hudson, Raina K. Plowright   +8 more
doaj   +1 more source