Results 191 to 200 of about 87,000,110 (295)

Advancing Pregnancy and Pediatric Science through the NIH Transporter Elucidation Network

Clinical Pharmacology &Therapeutics, EarlyView.
Human gestation is characterized by dynamic changes in maternal physiology and maturation of tissue functions before and after birth. The fetus and neonate are highly dependent upon transfer of maternal nutrients via the placenta and lactating mammary gland, which frequently involve selective membrane transporter proteins.
Joanne Wang, Jashvant D Unadkat, Samuel LM Arnold, John K Fallon, Pouria Fattahi, Dan Dongeun Huh, Nicholas Ieronimakis, Edward J Kelly, Svetlana Lutsenko, Robert M Stroud, Jacqueline B Tiley, Jia Yang, Xujia Zhou, Hao Zhu, Rajini Rao, Kathleen M Giacomini, Lauren M Aleksunes   +16 more
wiley   +1 more source

Machine learning-based prediction of large-for-gestational-age neonates in diabetic and non-diabetic pregnancies. [PDF]

Int J Gynaecol Obstet
Houri O, Romano A, Walfisch A, Hadar E, Gilboa Y, Perl L, Loebl N, Unger R.   +7 more
europepmc   +1 more source

Unbound Intrinsic Formation Clearance of 6β‐Hydroxycortisol Is a Useful Biomarker of CYP3A4 Activity during Pregnancy

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnancy results in multiple physiological changes that impact drug disposition. For example, hepatic CYP3A activity and renal transporter‐mediated clearance increase in late pregnancy, but the time course of these changes across pregnancy is not known.
Aurora K Authement, Mary F Hebert, Emily E Fay, Nina Isoherranen   +3 more
wiley   +1 more source

Gestational diabetes status modifies pre-pregnancy BMI associations with large for gestational age: A prospective cohort study in central China. [PDF]

Int J Gynaecol Obstet
Wu Y, Zhang J, Wang X, Chen L, Qin J, Wang T.   +5 more
europepmc   +1 more source

Proteomic Profiling of Xenobiotic and Nutrient Transporters in Human Placenta of Different Gestational Ages

Clinical Pharmacology &Therapeutics, EarlyView.
The placenta serves a critical role in nutrient uptake and waste elimination for the developing fetus. The placenta is also responsible for the uptake and/or exchange of xenobiotics, including medications, between the maternal and fetal bloodstreams. An estimated 40–80% of women take medications or drugs during pregnancy.
Eric M. Weaver, Ariel Topletz‐Erickson, Edward J. Kelly, Joanne Wang, Nina Isoherranen, Jashvant D. Unadkat, Samuel L.M. Arnold   +6 more
wiley   +1 more source

Association of plant-based diet with the risk of large-for-gestational-age birth in women with gestational diabetes mellitus. [PDF]

Nutr Metab (Lond)
Yin Y, Ye M, Shi M, Miao Z, Wang X, Lu S, Wu Y, Hu W, Fu Y.   +8 more
europepmc   +1 more source

Unintended Pregnancies and Breastfeeding Studies during Central Nervous System Drug Development: How Are they Handled, Is There Room for Improvement?

Clinical Pharmacology &Therapeutics, EarlyView.
Pregnant and breastfeeding individuals are routinely excluded from clinical drug development, creating persistent evidence gaps in pharmacology, safety, and dosing. Despite mandatory contraception and pregnancy testing, unintended pregnancies occur, particularly during the development of central nervous system (CNS) medicines used by women of ...
Sam Schoenmakers, Charlotte Bakker, Alexandra Ganev, Florence Butlen‐Ducuing, Corinne S. de Vries   +4 more
wiley   +1 more source

A nomogram to predict large-for-gestational-age in term newborns: A retrospective single-center study. [PDF]

Medicine (Baltimore)
Wu Y, Ma J.
europepmc   +1 more source

ESG Ratings and Firms' Engagement in Global Innovation Ecosystems: Implications for Green Innovation Capacity

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT The increasing salience of climate change has intensified attention to the roe of ESG ratings in shaping firms' green innovation. We examine the link between ESG performance and green innovation, highlighting the role of participation in global innovation networks.
Miaomiao Tao, David Roubaud, Mingzhi Zhang, Qianli Ma   +3 more
wiley   +1 more source

Elective induction versus expectant management for suspected large-for-gestational-age fetuses: a systematic review and meta-analysis. [PDF]

BMC Pregnancy Childbirth
Al-Qudah AA, Aleidi M, Alshebelat H, Al-Hanaktah M, Albadaineh R, Mullins E.   +5 more
europepmc   +1 more source