Results 131 to 140 of about 47,295 (298)

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Winter precipitation over the Iberian peninsula and its relationship to circulation indices [PDF]

Hydrology and Earth System Sciences, 2001
Winter precipitation variability over the Iberian peninsula was investigated by obtaining the spatial and temporal patterns. Empirical Orthogonal Functions were used to describe the variance distribution and to compress the precipitation data into a few ...
C. Rodríguez-Puebla, C. Rodríguez-Puebla, A. H. Encinas, J. Sáenz   +3 more
doaj  

Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Achieving High‐Density and Stress‐Resilient Maize Breeding Via Germplasm Innovation

Advanced Science, EarlyView.
Global population growth and climate change have exacerbated the global food crisis. This perspective presents a conceptual framework focusing on enhancing population advantages. Several novel breeding objectives are proposed to improve density tolerance and stress resistance for yield improvement.
Xinlong Li, Yongqiang Chen, Dong Ding, Xuehai Zhang, Xuxiang Jia, Zhanhui Zhang, Yafei Wang, Weihua Li, Hui Zhang, Jihua Tang   +9 more
wiley   +1 more source

Improvement of extreme events models by large-scale climate variability

, 2018
International audienceHydroclimatic extremes have severe consequences in all aspects of human life. During the last decade, several works revealed non-stationnarity and non-ergodicity of hydrological time series and their impacts on extreme events models.
Laignel, Benoît, B., Fossa, Manuel, Massei, Nicolas, Fournier, Matthieu, Turki, Imen   +4 more
core  

Remote Magnetomechanical Neuromodulation Uncovers Therapeutic Mechanisms for Alleviating Parkinsonian Symptoms in Freely Moving Mice

Advanced Science, EarlyView.
Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters, Lorenzo Signorelli, Christian Herff, Sophia Gimple, Renzo Riemens, Gunter Kenis, Kim Rijkers, Hamed Shabani, Jyh‐Jang Sun, Yasin Temel, Hans Clusmann, Danijela Gregurec, Sarah‐Anna Hescham   +12 more
wiley   +1 more source

A Correlative SICM‐OPM Platform for Surface and Volumetric Imaging in Live Cells

Advanced Science, EarlyView.
A multifunctional correlative imaging platform integrating Scanning Ion Conductance Microscopy (SICM) with Oblique Plane Microscopy (OPM) enables simultaneous surface topography, mechanical mapping, and 3D volumetric fluorescence imaging in live cells.
Wenzhi Hong, Ziwei Zhang, Ao Li, Ting Sun, Yunzhao Wu, Devkee M. Vadukul, Dylan Jones, Bing Li, Fengjie Liu, Francesco A. Aprile, Yuri Korchev, Julia Gorelik, David Klenerman, Andrew Shevchuk   +13 more
wiley   +1 more source

Autonomous and Continuous Atmospheric Water Harvesting Using Modified Wood

Advanced Science, EarlyView.
A rigid, hydroxyl‐rich wood skeleton with graded channels is used as a multifunctional host to co‐incorporate a PNipam/PAA network and LiCl, creating a high‐performance sorbent for atmospheric water harvesting. The composite achieves rapid sorption, efficient low‐temperature desorption, and stable cycling, enabling a solar‐powered device with a high ...
Shiheng He, Jiaqi Su, Tianting Leng, Yujian Song, Jidong Dong, Pengfei Huo, Zhenhua Gao, Shuaiyuan Han   +7 more
wiley   +1 more source

Testing the Performance of Tropical Cyclone Genesis Indices in Future Climates Using the HiRAM Model

, 2014
Tropical cyclone genesis indices (TCGIs) are functions of the large-scale environment that are designed to be proxies for the probability of tropical cyclone (TC) genesis.
Tippett, Michael K, Sobel, Adam H, Zhao, Ming, Camargo, Suzana J., Vecchi, Gabriel A., Tippett, Michael K., Vecchi, Gabriel A, Sobel, Adam H., Camargo, Suzana J   +8 more
core   +1 more source