Results 151 to 160 of about 48,825,372 (259)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Ocular Adverse Events Associated With Antidepressants: A Large-Scale Data Analysis From the FAERS Database. [PDF]

CNS Neurosci Ther
Peng Y, Cao Y, Liu H, Ma J, Yang G.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Large-Scale Data Analysis of Post-Traumatic Stress Disorder (PTSD) Through GWAS Fine-Mapping and Systems Biology. [PDF]

J Pers Med
Sharafshah A, Hanna C, Lewandrowski KU, Gold MS, Fuehrlein B, Thanos PK, Elman I, Gardner EL, Khalsa J, Baron D, Bowirrat A, Pinhasov A, Modestino EJ, Fiorelli RKA, Schmidt SL, Lorio MP, Sunder K, Fried L, Slifer M, Fornari F, Mahajan S, Mahajan Y, Lindenau M, Dowling Á, Dowling R, Bergamaschi JP, Thanos KZ, Carney PR, Blum K.   +28 more
europepmc   +1 more source

Weekday affects attendance rate for medical appointments: large-scale data analysis and implications. [PDF]

PLoS One, 2012
Ellis DA, Jenkins R.
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Factor Analysis for Multiple Testing (FAMT): An R Package for Large-Scale Significance Testing under Dependence [PDF]

The R package FAMT (factor analysis for multiple testing) provides a powerful method for large-scale significance testing under dependence. It is especially designed to select differentially expressed genes in microarray data when the correlation ...
Chloe Friguet, David Causeur, Magalie Houee-Bigot, Maela Kloareg   +3 more
core  

Proton pump inhibitors in systemic sclerosis: should we exercise caution? Insights from a large-scale data analysis. [PDF]

Clin Rheumatol
Tskhakaia I, Lema D, Tsibadze N, Lam JR, Subramanian A, Lau A.   +5 more
europepmc   +1 more source

Extraction of relations between genes and diseases from text and large-scale data analysis: implications for translational research. [PDF]

BMC Bioinformatics, 2015
Bravo À, Piñero J, Queralt-Rosinach N, Rautschka M, Furlong LI.   +4 more
europepmc   +1 more source