Results 131 to 140 of about 48,825,372 (259)

Large-Scale Data Stream Processing Systems

, 2017
In our data-centric society, online services, decision making, and other aspects are increasingly becoming heavily dependent on trends and patterns extracted from data.
Markl, V., Gábor Hermann, Asterios Katsifodimos, Gévay, G. E., Katsifodimos, A., Haridi, Seif,, Juan Soto, Volker Markl, Soto, J., Paris Carbone, Gábor E. Gévay, Hermann, G., Carbone, Paris,, Seif Haridi   +13 more
core   +1 more source

Identifying students’ solution strategies in digital mathematics assessment using log data

Large-scale Assessments in Education
Background Students take many tests and exams during their school career, but they usually receive feedback about their test performance based only on an analysis of the item responses.
Eva de Schipper, Remco Feskens, Franck Salles, Saskia Keskpaik, Reinaldo dos Santos, Bernard Veldkamp, Paul Drijvers   +6 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Statistical analysis of microarrays [PDF]

, 2005
Microarray statistical analysis involves thousands of hypothesis tests to consider at the same time. Empirical Bayes methods which are well-suited for large scale inference problems seem to be the most appropriate approach for microarray data.
Mouzaki, Daphne
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Who said large banks don't experience scale economies? Evidence from a risk-return-driven cost function [PDF]

Earlier studies found little evidence of scale economies at large banks; later studies using data from the 1990s uncovered such evidence, providing a rationale for very large banks seen worldwide.
Joseph P. Hughes, Loretta J. Mester
core  

Decomposition of a Large-Scale Energy Model [PDF]

, 1983
The modeling of energy systems generally involves the solution of very large scale linear programming problems which include descriptions of the energy transformation chains.
Nurminski, E.A., Balabanov, T.
core  

Data for: Scientific research driven by large-scale infrastructure projects: a case study of the Three Gorges Project in China

, 2018
Replication Data for: Scientific research driven by large-scale infrastructure projects: a case study of the Three Gorges Project in ...
jiang, H (via Mendeley Data), jiang, hanchen   +1 more
core   +1 more source