Results 71 to 80 of about 7,625,750 (291)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra +3 more
wiley +1 more source
A Large Scale Grid Data Analysis Platform for DSOs
Energies, 2017 The number of fluctuating distributed energy resources (DER) in electricity grids is continuously rising. Due to the lack of operational information on low-voltage (LV) networks, conservative assumptions are necessary to assess the connection of ...
Serdar Kadam +2 more
doaj +1 more source
Future Science OA, 2021 Aim: Providing compound data sets for promiscuity analysis with single-target (ST) and multi-target (MT) activity, taking confirmed inactivity against targets into account. Methodology: Compounds and target annotations are extracted from screening assays.
Christian Feldmann +2 more
doaj +1 more source
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Mango: Exploratory Data Analysis for Large-Scale Sequencing Datasets [PDF]
Cell Systems, 2019 The decreasing cost of DNA sequencing over the past decade has led to an explosion of sequencing datasets, leaving us with petabytes of data to analyze. However, current sequencing visualization tools are designed to run on single machines, which limits their scalability and interactivity on modern genomic datasets. Here, we leverage the scalability of
Alyssa Kramer, Morrow +6 more
openaire +2 more sources
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Distributed Data Strategies to Support Large-Scale Data Analysis Across Geo-Distributed Data Centers
IEEE Access, 2020 As the volume of data grows rapidly, storing big data in a single data center is no longer feasible. Hence, companies have developed two scenarios to store their big data in multiple data centers.
Tamer Z. Emara, Joshua Zhexue Huang
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The development and analysis of integrated neuroscience data
Frontiers in Computational Neuroscience, 2016 There is a strong emphasis on developing novel neuroscience technologies, in particular on recording from more neurons. There has thus been increasing discussion about how to analyze the resulting big datasets.
Joshua I Glaser +5 more
doaj +1 more source
Large-Scale Quality Analysis of Published ChIP-seq Data [PDF]
G3 Genes|Genomes|Genetics, 2014 Abstract ChIP-seq has become the primary method for identifying in vivo protein–DNA interactions on a genome-wide scale, with nearly 800 publications involving the technique appearing in PubMed as of December 2012. Individually and in aggregate, these data are an important and information-rich resource.
Marinov, Georgi K. +3 more
openaire +4 more sources