Results 91 to 100 of about 48,825,372 (259)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Secondary Data in Urban Analysis
, 2021 Data for use in urban analysis and planning research can come from many sources. One particular useful means of obtaining data is through the use of secondary data sources.
Scott Baum, Baum, Scott
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Fast principal component analysis of large-scale genome-wide data.
PLoS ONE, 2014 Principal component analysis (PCA) is routinely used to analyze genome-wide single-nucleotide polymorphism (SNP) data, for detecting population structure and potential outliers.
Gad Abraham, Michael Inouye
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A Large-Scale, Computerized Phonological
, 2003 INTRODUCTION Since the advent of Optimality Theory (Prince & Smolensky ####) there has been a dearth of large-scale analyses in the vein of The Sound Pattern of English (Chomsky & Halle ####) and Spanish Phonology (Harris ####).
Analysis Of Malagasy, Daniel M. Albro
core
Free-Text Collection-Level Subject Metadata in Large-Scale Digital Libraries: A Comparative Content Analysis [PDF]
, 2011 This paper reports results of the study that used an in-depth comparative content analysis to assess free-text collection-level subject metadata in three large-scale digital cultural heritage aggregations in the United States and ...
Zavalina, Oksana L., Zavalina, Oksana
core
Blackbox: A Large Scale Repository of Novice Programmers’ Activity [PDF]
, 2014 Automatically observing and recording the programming be- haviour of novices is an established computing education research technique. However, prior studies have been con- ducted at a single institution on a small or medium scale, without the ...
Neil C. C. Brown +8 more
core +1 more source
Impact of Climate Change and Heat Stress on Milk Production in Korean Holstein Cows: A Large-Scale Data Analysis. [PDF]
Animals (Basel), 2023 Jeon E, Jang S, Yeo JM, Kim DW, Cho K.
europepmc +1 more source