Results 101 to 110 of about 48,825,372 (259)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Interoperability of heterogeneous large-scale scientific workflows and data resources [PDF]
, 2011 Workflow allows e-Scientists to express their experimental processes in a structured way and provides a glue to integrate remote applications. Since Grid provides an enormously large amount of data and computational resources, executing workflows on the ...
Kukla, T.
core +1 more source
FuncTree: Functional Analysis and Visualization for Large-Scale Omics Data.
PLoS ONE, 2015 Exponential growth of high-throughput data and the increasing complexity of omics information have been making processing and interpreting biological data an extremely difficult and daunting task. Here we developed FuncTree (http://bioviz.tokyo/functree),
Takeru Uchiyama +4 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Social Engineering Threat Analysis Using Large-Scale Synthetic Data
Journal of Informatics and Web EngineeringWe frequently hear news about compromised systems, virus attacks, spam emails, stolen bank account numbers, and loss of money. Safeguarding and protecting digital assets against these and other cyber-attacks are extremely important in our digital ...
Sellappan Palaniappan +3 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
, 2011 This presentation includes audio/video media and discusses metadata. This presentation reports results of the study that used an in-depth comparative content analysis to assess free-text collection-level subject metadata in three large-scale digital ...
Zavalina, Oksana
core
Large-Scale Data Analysis for Glucose Variability Outcomes with Open-Source Automated Insulin Delivery Systems. [PDF]
Nutrients, 2022 Shahid A, Lewis DM.
europepmc +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source