Results 81 to 90 of about 5,780,328 (293)

New Trends in Large Scale Distributed Systems Simulation

Journal of Algorithms & Computational Technology, 2011
In this paper we present recent developments in the domain of modeling and simulation of large scale distributed systems (LSDS). Such systems possess features that include resource sharing, openness, concurrency, scalability, fault-tolerance, and ...
Ciprian Dobre, Florin Pop, Valentin Cristea   +2 more
doaj   +1 more source

Large-scale systems: Complexity, stability, reliability [PDF]

After showing that a complex dynamic system with a competitive structure has highly reliable stability, a class of noncompetitive dynamic systems for which competitive models can be constructed is defined. It is shown that such a construction is possible
Siljak, D. D.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Prospects for large-scale financial systems simulation

, 2011
As the 21st century unfolds, we find ourselves having to control, support, manage or otherwise cope with large-scale complex adaptive systems to an extent that is unprecedented in human history.
Bullock, Seth
core  

Large-scale periodicity in the distribution of QSO absorption-line systems

, 2010
The spatial-temporal distribution of absorption-line systems (ALSs) observed in QSO spectra within the cosmological redshift interval z = 0.0--4.3 is investigated on the base of our updated catalog of absorption systems.
A. D. Kaminker, A. Dekel, A. I. Ryabinkov, A.D. Kaminker, A.G. Doroshkevich, A.I. Ryabinkov, A.I. Ryabinkov, A.J.S. Hamilton, A.R. Rivolo, B. Ménard, B.F. Lundgren, C. Blake, D.J. Eisenstein, D.J. Eisenstein, D.J. Eisenstein, E. Gaztañaga, E. Gaztañaga, E. Harrison, E. Tago, E.A. Kazin, G.E. Prochter, G.G. Kacprzak, G.G. Kacprzak, H. Kurki-Suonio, H.J. Mo, I.Ya. Aref’eva, J. Einasto, J. Einasto, J.A. Peacock, J.G. Hartnett, J.G. Hartnett, J.M. Quashnock, K. Hirano, M. Bath, M. Davis, M. Einasto, M. Kerscher, M. Morikawa, M.B. Bell, N. Bouché, N. Kaiser, N. Yoshida, P.J.E. Peebles, R. Kayser, R. Weygaert van de, S.D. Landy, T.J. Broadhurst, V. Junkkarinen, V.J. Martínez, W. Mattig, W.J. Percival, W.J. Percival   +51 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Distributing the Kalman Filter for Large-Scale Systems

, 2008
This paper derives a \emph{distributed} Kalman filter to estimate a sparsely connected, large-scale, $n-$dimensional, dynamical system monitored by a network of $N$ sensors. Local Kalman filters are implemented on the ($n_l-$dimensional, where $n_l\ll n$)
Khan, Usman A., Moura, Jose M. F.
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hydrology objects monitoring system

Системный анализ и прикладная информатика, 2019
The article deals with the results of the development of monitoring system of potentially dangerous hydro-objects. The formal statement of the problem, models of the monitoring scene and its participants are presented.
A. I. Kuzmich, O. V. Baranovski, A. N. Valvachev   +2 more
doaj   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source