Results 121 to 130 of about 1,581 (277)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Issues raised by Ruthrof’s ’Meaning: An intersemiotic perspective’
, 1997 In 'Meaning: An intersemiotic perspective', Ruthrof argues that the entirety of human experience can be construed in terms of sign systems. Following Peirce, who maintains that we think only in signs, he says: ...
King, D.
core
Measurability Properties on Small Cardinals [PDF]
, 2014 Ulam proved that there cannot exist a probability measure on the reals for which every set is measurable and gets either measure zero or one. He asked how large a collection of partial 0-1 valued measures is required so that every set of reals is ...
Eskew, Monroe Blake
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Forcing axioms and the complexity of non-stationary ideals. [PDF]
Mon Hefte Math, 2022 Cox S, Lücke P.
europepmc +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Global Chang's Conjecture and singular cardinals. [PDF]
Eur J Math, 2021 Eskew M, Hayut Y.
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Neural tuning instantiates prior expectations in the human visual system. [PDF]
Nat Commun, 2023 Harrison WJ, Bays PM, Rideaux R.
europepmc +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source